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CYB5R3

CYB5R3 (Cytochrome B5 Reductase 3) is a Protein Coding gene. Diseases associated with CYB5R3 include Methemoglobinemia Due To Deficiency Of Methemoglobin Reductase and Hereditary Methemoglobinemia. Among its related pathways are Innate Immune System and Metabolism. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and NAD binding. An important paralog of this gene is CYB5R1.
Full Name
Cytochrome B5 Reductase 3
Function
Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.
Biological Process
Blood circulation Source: ProtInc
Cholesterol biosynthetic process Source: UniProtKB-KW
L-ascorbic acid metabolic process Source: Reactome
Neutrophil degranulation Source: Reactome
Nitric oxide biosynthetic process Source: FlyBase
Xenobiotic metabolic process Source: Reactome
Cellular Location
Isoform 1: Endoplasmic reticulum membrane; Mitochondrion outer membrane
Isoform 2: Cytoplasm. Produces the soluble form found in erythrocytes.
Involvement in disease
Methemoglobinemia CYB5R3-related (METHB-CYB5R3):
A form of methemoglobinemia, a hematologic disease characterized by the presence of excessive amounts of methemoglobin in blood cells, resulting in decreased oxygen carrying capacity of the blood, cyanosis and hypoxia. There are two types of methemoglobinemia CYB5R3-related. In type 1, the defect affects the soluble form of the enzyme, is restricted to red blood cells, and causes well-tolerated methemoglobinemia. In type 2, the defect affects both the soluble and microsomal forms of the enzyme and is thus generalized, affecting red cells, leukocytes and all body tissues. Type 2 methemoglobinemia is associated with mental deficiency and other neurologic symptoms.

Anti-CYB5R3 antibodies

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Target: CYB5R3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Dog
Clone: 2A10
Application*: WB, F, IH, P
Target: CYB5R3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2A9
Application*: E
Target: CYB5R3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Dog
Clone: CBFYC-2552
Application*: WB, F, IH, P
Target: CYB5R3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-2554
Application*: WB, IH, IF
Target: CYB5R3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1979
Application*: WB, IF
Target: CYB5R3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXC-3119
Application*: E, IF, IH, WB
Target: CYB5R3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Dog, Monkey
Clone: CBWJC-3505
Application*: WB, IH, F
Target: CYB5R3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1E3
Application*: IC/IF, WB
Target: CYB5R3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1E8
Application*: IF, P, WB
Target: CYB5R3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CF128
Application*: ELISA, WB, IHC, IF
Target: CYB5R3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 227
Application*: ELISA, IF, IHC, WB
Target: CYB5R3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG879
Application*: WB: 1:500~1:1000 IHC: 1:50~1:100 ELISA: 1:40000
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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