Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-CSNK1E Recombinant Antibody (CBFYC-2296) (V2LY-0125-LY17)


See all CSNK1E antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human, Chicken, Dog, Mouse, Rat, Pig, Horse
Clone
CBFYC-2296
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 371-402 near the C-terminus of human casein kinase Iε.
Host Species
Mouse
Specificity
Human, Chicken, Dog, Mouse, Rat, Pig, Horse
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:100-1:1,000
IP1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Gelatin & PBS
Preservative
Sodium Azide
Concentration
0.2 mg/mL
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CSNK1E
Entrez Gene ID
Human1454
Mouse27373
Rat58822
Chicken378891
Dog474510
UniProt ID
HumanP49674
MouseQ9JMK2
RatQ9JJ76
ChickenQ5ZLL1
DogE2RA08
Function
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation.
Biological Process
Canonical Wnt signaling pathway Source: WormBase
Ciliary basal body-plasma membrane docking Source: Reactome
Circadian regulation of gene expression Source: UniProtKB
DNA repair Source: ProtInc
Endocytosis Source: GO_Central
G2/M transition of mitotic cell cycle Source: Reactome
Negative regulation of protein binding Source: ParkinsonsUK-UCL
Peptidyl-serine phosphorylation Source: ParkinsonsUK-UCL
Positive regulation of canonical Wnt signaling pathway Source: GO_Central
Positive regulation of non-canonical Wnt signaling pathway Source: ParkinsonsUK-UCL
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
Positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation Source: ParkinsonsUK-UCL
Protein phosphorylation Source: UniProtKB
Regulation of cellular protein localization Source: ParkinsonsUK-UCL
Regulation of circadian rhythm Source: UniProtKB
Regulation of G2/M transition of mitotic cell cycle Source: Reactome
Signal transduction Source: ProtInc
Wnt signaling pathway Source: GO_Central
Cellular Location
Cytoplasm; Nucleus
PTM
Autophosphorylated. Partially dephosphorylated by PPP5C. May be dephosphorylated by PP1.
More Infomation

Zhou, L., Fitzpatrick, K., Olker, C., Vitaterna, M. H., & Turek, F. W. (2021). Casein kinase 1 epsilon and circadian misalignment impact affective behaviours in mice. European Journal of Neuroscience.

Zhou, L., Fitzpatrick, K., Olker, C., Vitaterna, M. H., & Turek, F. W. (2020). Altered Affective Behaviors in Casein Kinase 1 Epsilon Mutant Mice. bioRxiv.

Guo, G., Wang, K., Hu, S. S., Tian, T., Liu, P., Mori, T., ... & Qin, X. (2019). Autokinase activity of casein kinase 1 δ/ε governs the period of mammalian circadian rhythms. Journal of biological rhythms, 34(5), 482-496.

Lin, S. H., Chen, M. K., Chang, J. H., Velmurugan, B. K., Annamanedi, M., Su, S. C., ... & Yang, S. F. (2019). Impact of polymorphisms in casein kinase 1 epsilon and environmental factors in oral cancer susceptibility. Journal of Cancer, 10(21), 5065.

Lee, K. Y., Ahn, Y. M., Kim, S. H., Kang, H. G., & Joo, E. J. (2018). Genetic association study of CSNK1E gene in bipolar disorder and circadian characteristics. Nordic Journal of Psychiatry, 72(8), 599-604.

Bar, I., Merhi, A., Larbanoix, L., Constant, M., Haussy, S., Laurent, S., ... & Delrée, P. (2018). Silencing of casein kinase 1 delta reduces migration and metastasis of triple negative breast cancer cells. Oncotarget, 9(56), 30821.

Varghese, R. T., Young, S., Pham, L., Liang, Y., Pridham, K. J., Guo, S., ... & Sheng, Z. (2018). Casein kinase 1 epsilon regulates glioblastoma cell survival. Scientific reports, 8(1), 1-13.

Janovska, P., Verner, J., Kohoutek, J., Bryjova, L., Gregorova, M., Dzimkova, M., ... & Bryja, V. (2018). Casein kinase 1 is a therapeutic target in chronic lymphocytic leukemia. Blood, The Journal of the American Society of Hematology, 131(11), 1206-1218.

Goldberg, L. R., Kirkpatrick, S. L., Yazdani, N., Luttik, K. P., Lacki, O. A., Keith Babbs, R., ... & Bryant, C. D. (2017). Casein kinase 1‐epsilon deletion increases mu opioid receptor‐dependent behaviors and binge eating 1. Genes, Brain and Behavior, 16(7), 725-738.

Morgenstern, Y., Das Adhikari, U., Ayyash, M., Elyada, E., Tóth, B., Moor, A., ... & Ben‐Neriah, Y. (2017). Casein kinase 1‐epsilon or 1‐delta required for Wnt‐mediated intestinal stem cell maintenance. The EMBO journal, 36(20), 3046-3061.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-CSNK1E Recombinant Antibody (CBFYC-2296)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry