CSF1

CSF1 (Colony Stimulating Factor 1) is a Protein Coding gene. Diseases associated with CSF1 include Pigmented Villonodular Synovitis and Tenosynovial Giant Cell Tumor. Among its related pathways are Akt Signaling and Rheumatoid arthritis. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and growth factor activity.

Colony Stimulating Factor 1

Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.

Branching involved in mammary gland duct morphogenesis Source: Ensembl
Cellular protein metabolic process Source: Reactome
Cytokine-mediated signaling pathway Source: Reactome
Developmental process involved in reproduction Source: BHF-UCL
Homeostasis of number of cells within a tissue Source: Ensembl
Inflammatory response Source: UniProtKB-KW
Innate immune response Source: UniProtKB-KW
Macrophage colony-stimulating factor signaling pathway Source: Ensembl
Macrophage differentiation Source: UniProtKB
Mammary duct terminal end bud growth Source: Ensembl
Mammary gland fat development Source: Ensembl
Microglial cell proliferation Source: Ensembl
Monocyte activation Source: BHF-UCL
Negative regulation of neuron death Source: ARUK-UCL
Osteoclast differentiation Source: BHF-UCL
Osteoclast proliferation Source: Ensembl
Positive regulation of cell-matrix adhesion Source: BHF-UCL
Positive regulation of cell migration Source: BHF-UCL
Positive regulation of cell population proliferation Source: MGI
Positive regulation of cellular protein metabolic process Source: BHF-UCL
Positive regulation of gene expression Source: BHF-UCL
Positive regulation of macrophage chemotaxis Source: BHF-UCL
Positive regulation of macrophage colony-stimulating factor signaling pathway Source: BHF-UCL
Positive regulation of macrophage derived foam cell differentiation Source: BHF-UCL
Positive regulation of macrophage differentiation Source: BHF-UCL
Positive regulation of microglial cell migration Source: BHF-UCL
Positive regulation of monocyte differentiation Source: BHF-UCL
Positive regulation of mononuclear cell proliferation Source: BHF-UCL
Positive regulation of multicellular organism growth Source: Ensembl
Positive regulation of odontogenesis of dentin-containing tooth Source: Ensembl
Positive regulation of osteoclast differentiation Source: BHF-UCL
Positive regulation of protein kinase activity Source: BHF-UCL
Positive regulation of Ras protein signal transduction Source: Ensembl
Post-translational protein modification Source: Reactome
Regulation of macrophage derived foam cell differentiation Source: BHF-UCL
Regulation of ossification Source: Ensembl
Response to ischemia Source: ARUK-UCL
Transmembrane receptor protein tyrosine kinase signaling pathway Source: BHF-UCL

Cell membrane
Processed macrophage colony-stimulating factor 1: Extracellular space

Aberrant expression of CSF1 or CSF1R can promote cancer cell proliferation, invasion and formation of metastases. Overexpression of CSF1 or CSF1R is observed in a significant percentage of breast, ovarian, prostate, and endometrial cancers.
Aberrant expression of CSF1 or CSF1R may play a role in inflammatory diseases, such as rheumatoid arthritis, glomerulonephritis, atherosclerosis, and allograft rejection.

Lumenal: 33-496
Helical: 497-517
Cytoplasmic: 518-554

N- and O-glycosylated. Glycosylation and proteolytic cleavage yield different soluble forms. One high molecular weight soluble form is a proteoglycan containing chondroitin sulfate. O-glycosylated with core 1 or possibly core 8 glycans. Isoform 1 is N- and O-glycosylated. Isoform 3 is only N-glycosylated.