Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Rat Anti-CSF1 Recombinant Antibody (CBFYM-0153) (V2LY-1206-LY1384)


See all CSF1 antibodies
Online Inquiry

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBFYM-0153
Antibody Isotype
IgG2b
Application
WB, Neutralization

Basic Information

Immunogen
Recombinant mouse M-CSF Lys33-Glu262.
Host Species
Rat
Specificity
Mouse
Antibody Isotype
IgG2b
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Colony Stimulating Factor 1
Entrez Gene ID
12977
UniProt ID
P07141
Function
Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.
Biological Process
Branching involved in mammary gland duct morphogenesis Source: Ensembl
Cellular protein metabolic process Source: Reactome
Cytokine-mediated signaling pathway Source: Reactome
Developmental process involved in reproduction Source: BHF-UCL
Homeostasis of number of cells within a tissue Source: Ensembl
Inflammatory response Source: UniProtKB-KW
Innate immune response Source: UniProtKB-KW
Macrophage colony-stimulating factor signaling pathway Source: Ensembl
Macrophage differentiation Source: UniProtKB
Mammary duct terminal end bud growth Source: Ensembl
Mammary gland fat development Source: Ensembl
Microglial cell proliferation Source: Ensembl
Monocyte activation Source: BHF-UCL
Negative regulation of neuron death Source: ARUK-UCL
Osteoclast differentiation Source: BHF-UCL
Osteoclast proliferation Source: Ensembl
Positive regulation of cell-matrix adhesion Source: BHF-UCL
Positive regulation of cell migration Source: BHF-UCL
Positive regulation of cell population proliferation Source: MGI
Positive regulation of cellular protein metabolic process Source: BHF-UCL
Positive regulation of gene expression Source: BHF-UCL
Positive regulation of macrophage chemotaxis Source: BHF-UCL
Positive regulation of macrophage colony-stimulating factor signaling pathway Source: BHF-UCL
Positive regulation of macrophage derived foam cell differentiation Source: BHF-UCL
Positive regulation of macrophage differentiation Source: BHF-UCL
Positive regulation of microglial cell migration Source: BHF-UCL
Positive regulation of monocyte differentiation Source: BHF-UCL
Positive regulation of mononuclear cell proliferation Source: BHF-UCL
Positive regulation of multicellular organism growth Source: Ensembl
Positive regulation of odontogenesis of dentin-containing tooth Source: Ensembl
Positive regulation of osteoclast differentiation Source: BHF-UCL
Positive regulation of protein kinase activity Source: BHF-UCL
Positive regulation of Ras protein signal transduction Source: Ensembl
Post-translational protein modification Source: Reactome
Regulation of macrophage derived foam cell differentiation Source: BHF-UCL
Regulation of ossification Source: Ensembl
Response to ischemia Source: ARUK-UCL
Transmembrane receptor protein tyrosine kinase signaling pathway Source: BHF-UCL
Cellular Location
Cell membrane
Processed macrophage colony-stimulating factor 1: Extracellular space
Involvement in disease
Aberrant expression of CSF1 or CSF1R can promote cancer cell proliferation, invasion and formation of metastases. Overexpression of CSF1 or CSF1R is observed in a significant percentage of breast, ovarian, prostate, and endometrial cancers.
Aberrant expression of CSF1 or CSF1R may play a role in inflammatory diseases, such as rheumatoid arthritis, glomerulonephritis, atherosclerosis, and allograft rejection.
Topology
Lumenal: 33-496
Helical: 497-517
Cytoplasmic: 518-554
PTM
N- and O-glycosylated. Glycosylation and proteolytic cleavage yield different soluble forms. One high molecular weight soluble form is a proteoglycan containing chondroitin sulfate. O-glycosylated with core 1 or possibly core 8 glycans. Isoform 1 is N- and O-glycosylated. Isoform 3 is only N-glycosylated.
More Infomation

Yu, X., Basbaum, A., & Guan, Z. (2021). Contribution of colony-stimulating factor 1 to neuropathic pain. Pain reports, 6(1).

Kaur, S., Sehgal, A., Wu, A. C., Millard, S. M., Batoon, L., Sandrock, C. J., ... & Pettit, A. R. (2021). Stable colony-stimulating factor 1 fusion protein treatment increases hematopoietic stem cell pool and enhances their mobilisation in mice. Journal of Hematology & Oncology, 14(1), 1-19.

Pognan, F., Couttet, P., Demin, I., Jaitner, B., Pang, Y., Roubenoff, R., ... & Schramm, U. (2019). Colony-stimulating factor-1 antibody lacnotuzumab in a phase 1 healthy volunteer study and mechanistic investigation of safety outcomes. Journal of Pharmacology and Experimental Therapeutics, 369(3), 428-442.

Zhu, Y., Yang, J., Xu, D., Gao, X. M., Zhang, Z., Hsu, J. L., ... & Qin, L. X. (2019). Disruption of tumour-associated macrophage trafficking by the osteopontin-induced colony-stimulating factor-1 signalling sensitises hepatocellular carcinoma to anti-PD-L1 blockade. Gut, 68(9), 1653-1666.

Okugawa, Y., Toiyama, Y., Ichikawa, T., Kawamura, M., Yasuda, H., Fujikawa, H., ... & Kusunoki, M. (2018). Colony-stimulating factor-1 and colony-stimulating factor-1 receptor co-expression is associated with disease progression in gastric cancer. International journal of oncology, 53(2), 737-749.

Kumari, A., Silakari, O., & Singh, R. K. (2018). Recent advances in colony stimulating factor-1 receptor/c-FMS as an emerging target for various therapeutic implications. Biomedicine & Pharmacotherapy, 103, 662-679.

Wohleb, E. S., Terwilliger, R., Duman, C. H., & Duman, R. S. (2018). Stress-induced neuronal colony stimulating factor 1 provokes microglia-mediated neuronal remodeling and depressive-like behavior. Biological psychiatry, 83(1), 38-49.

Cannarile, M. A., Weisser, M., Jacob, W., Jegg, A. M., Ries, C. H., & Rüttinger, D. (2017). Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy. Journal for immunotherapy of cancer, 5(1), 1-13.

Papadopoulos, K. P., Gluck, L., Martin, L. P., Olszanski, A. J., Tolcher, A. W., Ngarmchamnanrith, G., ... & Stephenson, J. (2017). First-in-human study of AMG 820, a monoclonal anti-colony-stimulating factor 1 receptor antibody, in patients with advanced solid tumors. Clinical Cancer Research, 23(19), 5703-5710.

Walker, D. G., Tang, T. M., & Lue, L. F. (2017). Studies on colony stimulating factor receptor-1 and ligands colony stimulating factor-1 and interleukin-34 in Alzheimer's disease brains and human microglia. Frontiers in aging neuroscience, 9, 244.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rat Anti-CSF1 Recombinant Antibody (CBFYM-0153)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quoteOnline Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry