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CRYAB

CRYAB (Crystallin Alpha B) is a Protein Coding gene. Diseases associated with CRYAB include Myopathy, Myofibrillar, 2 and Cataract 16, Multiple Types. Among its related pathways are Protein processing in endoplasmic reticulum and Longevity regulating pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and microtubule binding. An important paralog of this gene is CRYAA.
Full Name
Crystallin Alpha B
Function
May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
Biological Process
Apoptotic process involved in morphogenesis Source: Ensembl
Cellular response to gamma radiation Source: MGI
Lens development in camera-type eye Source: Ensembl
Microtubule polymerization or depolymerization Source: Ensembl
Multicellular organism aging Source: Ensembl
Muscle contraction Source: ProtInc
Muscle organ development Source: Ensembl
Negative regulation of amyloid fibril formation Source: ARUK-UCL
Negative regulation of apoptotic process Source: HGNC-UCL
Negative regulation of cell growth Source: Ensembl
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
Negative regulation of gene expression Source: Ensembl
Negative regulation of intracellular transport Source: HGNC-UCL
Negative regulation of protein-containing complex assembly Source: ARUK-UCL
Negative regulation of reactive oxygen species metabolic process Source: Ensembl
Negative regulation of transcription, DNA-templated Source: UniProtKB
Protein folding Source: ProtInc
Protein stabilization Source: CAFA
Regulation of cell death Source: MGI
Regulation of cellular response to heat Source: Reactome
Response to estradiol Source: Ensembl
Response to hydrogen peroxide Source: Ensembl
Response to hypoxia Source: Ensembl
Stress-activated MAPK cascade Source: Ensembl
Tubulin complex assembly Source: Ensembl
Cellular Location
Cytoplasm; Nucleus; Secreted. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles (PubMed:19464326). Localizes at the Z-bands and the intercalated disk in cardiomyocytes (PubMed:28493373). Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059).
Involvement in disease
Myopathy, myofibrillar, 2 (MFM2):
A form of myofibrillar myopathy, a group of chronic neuromuscular disorders characterized at ultrastructural level by disintegration of the sarcomeric Z disk and myofibrils, and replacement of the normal myofibrillar markings by small dense granules, or larger hyaline masses, or amorphous material. MFM2 is characterized by weakness of the proximal and distal limb muscles, weakness of the neck, velopharynx and trunk muscles, hypertrophic cardiomyopathy, and cataract in a subset of patients.
Cataract 16, multiple types (CTRCT16):
An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. CTRCT16 includes posterior polar cataract, among others. Posterior polar cataract is a subcapsular opacity, usually disk-shaped, located at the back of the lens.
CRYAB mutations may be involved in restrictive cardiomyopathy (RCM), a rare non-ischemic myocardial disease. RCM is characterized by restrictive ventricular-filling physiology in the presence of normal or reduced diastolic and/or systolic volumes (of 1 or both ventricles), biatrial enlargement, and normal ventricular wall thickness.
Myopathy, myofibrillar, fatal infantile hypertonic, alpha-B crystallin-related (MFMFIH-CRYAB):
A form of myofibrillar myopathy, a group of chronic neuromuscular disorders characterized at ultrastructural level by disintegration of the sarcomeric Z disk and myofibrils, and replacement of the normal myofibrillar markings by small dense granules, or larger hyaline masses, or amorphous material. MFMFIH-CRYAB has onset in the first weeks of life after a normal neonatal period. Affected infants show rapidly progressive muscular rigidity of the trunk and limbs associated with increasing respiratory difficulty resulting in death before age 3 years.
Cardiomyopathy, dilated 1II (CMD1II):
A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.

Anti-CRYAB antibodies

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Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2040
Application*: WB, IH, IF, F
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2627
Application*: WB, IF
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2242
Application*: WB, IH, F, IP
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3138
Application*: WB, IH, IF, F, IP
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3137
Application*: WB, IH, F, IP
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3136
Application*: IF, F, IP
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Cattle
Clone: CBFYC-0362
Application*: WB
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1D11C6E6
Application*: WB, IH, E
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Human, Mouse, Rat, Chicken
Clone: 1B6.1-3G4
Application*: F, IC, C, IP, WB
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Cattle
Clone: 1A7.D5
Application*: E, WB
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2851
Application*: WB, IF, IP
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2474
Application*: E, P, WB
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG2c
Specificity: Human
Clone: 5BA6
Application*: E, WB
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBWJC-3140
Application*: WB, IH, F, IP
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBWJC-3139
Application*: WB, IH, IF, F, IP
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Monkey
Clone: CBXC-2999
Application*: WB, IH, IF, F, IP
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXC-1610
Application*: E, WB
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: GF1
Application*: E, WB
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXC-0574
Application*: WB
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXC-2466
Application*: E, WB
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Human, Pig, Rat
Clone: 1A7.D5
Application*: ICC/IF, ELISA, WB
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: S4
Application*: WB
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: P2E8AT
Application*: E, WB
Target: CRYAB
Host: Rabbit
Specificity: Human, Mouse, Rat
Clone: D6S9E
Application*: WB, IP
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 13B197
Application*: E, IH, WB
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3141
Application*: E, WB
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 11C236
Application*: WB
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-2250
Application*: F, IF, IP
Target: CRYAB
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Application*: WB, P, IF
Target: CRYAB
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Cattle
Application*: WB, IH, P, IF
Target: CRYAB
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Application*: IF, P
Target: CRYAB
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Cattle
Application*: WB, IC, IF
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-2249
Application*: E, WB
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYY-C0585
Application*: E, WB
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Chicken, Human, Rat
Clone: CBYY-C0277
Application*: WB
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Human, Mouse, Rat, Chicken
Clone: CBFYC-2248
Application*: WB, P
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG2a, IgG2b
Specificity: Human
Clone: CBFYC-2247
Application*: E, IH
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1D11C6E6
Application*: WB, IHC
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Chicken, Human, Rat
Clone: 4E55
Application*: WB
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Cattle
Clone: CBCNC-374
Application*: E, WB, P
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBCNC-373
Application*: E, WB
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1A10-1A4
Application*: E, WB
Target: CRYAB
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Application*: WB, P, IF
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2887
Application*: IF, IP, WB
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 7G26
Application*: E, WB
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 6G5
Application*: F, P, IP, WB
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: 2E8
Application*: E, WB
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Cattle
Clone: 3A10.C9
Application*: P, E, WB
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Cattle
Clone: 3A10.H4
Application*: WB, IC, IF
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4A6
Application*: F, IC, IF, IH, P, WB
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: 6A9
Application*: F, IC, IF, IH, P, WB
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey, Rat
Clone: 6D11
Application*: F, IC, IF, IH, P, WB
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: CBYC-A945
Application*: WB
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Human, Mouse
Clone: 10F695
Application*: E, WB
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: 10B2611
Application*: E, WB
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10B2612
Application*: E, WB
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 10D5F4
Application*: E, IH
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 1329CT523.140.120
Application*: WB
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1G1
Application*: F, IF
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2A1
Application*: C, WB
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3 E3
Application*: WB
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Human
Clone: 3A10-H4
Application*: E, P, WB
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3C2
Application*: F, P, IP, WB
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3E3
Application*: IF, IP, WB
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4E8-1C5
Application*: E, WB
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5C9
Application*: IF, C, WB
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5D8
Application*: IF, WB
Target: CRYAB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5F12-B10
Application*: P, WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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