CRTC3

CRTC3 (CREB Regulated Transcription Coactivator 3) is a Protein Coding gene. Diseases associated with CRTC3 include Human T-Cell Leukemia Virus Type 1 and Mucoepidermoid Carcinoma. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial Gene Expression. Gene Ontology (GO) annotations related to this gene include cAMP response element binding protein binding. An important paralog of this gene is CRTC2.

CREB Regulated Transcription Coactivator 3

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).

Energy homeostasis Source: Ensembl
Macrophage activation Source: CACAO
Negative regulation of cAMP-mediated signaling Source: Ensembl
Negative regulation of lipid catabolic process Source: Ensembl
Positive regulation of CREB transcription factor activity Source: GO_Central
Positive regulation of transcription by RNA polymerase II Source: GO_Central
Protein homotetramerization Source: InterPro
Viral process Source: UniProtKB-KW

Nucleus; Cytoplasm. Appears to be mainly nuclear (PubMed:15454081). Translocates to the nucleus following adenylyl cyclase or MAP kinase activation (PubMed:30611118).

Phosphorylation/dephosphorylation states of Ser-273 are required for regulating transduction of CREB activity (By similarity). CRTCs/TORCs are inactive when phosphorylated, and active when dephosphorylated at this site (By similarity). May be phosphorylated at Ser-391 by MAPK3/ERK1 and/or MAPK1/ERK2 or by some cyclin-dependent kinases such as CDK1,CDK2 or CDK5 (PubMed:30611118). Following adenylyl cyclase activation, dephosphorylated at Ser-162 and Ser-273 resulting in its dissociation from 14-3-3 proteins probably promoting CRTC3 translocation into the nucleus (PubMed:30611118).