CPE

CPE (Carboxypeptidase E) is a Protein Coding gene. Diseases associated with CPE include Hyperproinsulinemia and Phlebotomus Fever. Among its related pathways are Peptide hormone metabolism and Allograft rejection. Gene Ontology (GO) annotations related to this gene include cell adhesion molecule binding and carboxypeptidase activity. An important paralog of this gene is CPD.

Full Name

Carboxypeptidase E

Function

Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage.

Biological Process

Cardiac left ventricle morphogenesis Source: BHF-UCL
Cellular protein modification process Source: UniProtKB
Neuropeptide signaling pathway Source: UniProtKB
Peptide metabolic process Source: GO_Central
Protein localization to membrane Source: BHF-UCL
Protein processing Source: GO_Central
Wnt signaling pathway Source: CACAO

Cellular Location

Isoform 1: Secreted; Secretory vesicle; Secretory vesicle membrane. Associated with the secretory granule membrane through direct binding to lipid rafts in intragranular conditions.

Anti-CPE antibodies

Mouse Anti-CPE Recombinant Antibody (CBXC-1179) (CBMAB-C1445-CQ)

Datasheet

SDS

Target: CPE

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXC-1179

Application*: WB, IP

Rabbit Anti-CPE Recombinant Antibody (CBFYC-2156) (CBMAB-C2224-FY)

Datasheet

SDS

Target: CPE

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBFYC-2156

Application*: E

Rabbit Anti-CPE Recombinant Antibody (EG801) (CBMAB-EN957-LY)

Datasheet

SDS

Target: CPE

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: EG801

Application*: WB: 1:500~1:1000 ELISA: 1:5000

Mouse Anti-CPE Recombinant Antibody (8H180) (CBMAB-C2750-CN)

Datasheet

SDS

Target: CPE

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 8H180

Application*: E, IP, WB

Mouse Anti-CPE Recombinant Antibody (CBYY-C0036) (CBMAB-C0102-YY)

Datasheet

SDS

Target: CPE

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rat, Human, Mouse

Clone: CBYY-C0036

Application*: WB, IF, IH

Mouse Anti-CPE Recombinant Antibody (420709/M8100701) (CBMAB-C6461-LY)

Datasheet

SDS

Target: CPE

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 420709/M8100701

Application*: E, IP, WB

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)