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COX4I1

COX4I1 (Cytochrome C Oxidase Subunit 4I1) is a Protein Coding gene. Diseases associated with COX4I1 include Calvarial Hyperostosis and Exocrine Pancreatic Insufficiency. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Gene Expression. Gene Ontology (GO) annotations related to this gene include cytochrome-c oxidase activity. An important paralog of this gene is COX4I2.
Full Name
Cytochrome C Oxidase Subunit 4I1
Alternative Names
Cytochrome C Oxidase Subunit 4I1; Cytochrome C Oxidase Subunit IV Isoform 1; Cytochrome C Oxidase Polypeptide IV; Cytochrome C Oxidase Subunit IV; COX IV-1; COX4;
Function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunbit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Biological Process
Generation of precursor metabolites and energy Source: ProtInc
Mitochondrial electron transport, cytochrome c to oxygen Source: GO_Central
Response to nutrient Source: Ensembl
Cellular Location
Mitochondrion inner membrane
Involvement in disease
Mitochondrial complex IV deficiency, nuclear type 16 (MC4DN16):
An autosomal recessive mitochondrial disorder with onset in infancy and variable manifestations. MC4DN16 features include feeding difficulties, poor overall growth, short stature, microcephaly, developmental regression, severe hypotonia, and seizures. Cerebral and cerebellar atrophy, and abnormal lesions in the basal ganglia can be observed on brain imaging. Patient tissues show decreased levels and activity of mitochondrial respiratory complex IV.
Topology
Mitochondrial matrix: 23-98
Helical: 99-124
Mitochondrial intermembrane: 125-169

Anti-COX4I1 antibodies

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Target: COX4I1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EC127
Application*: WB, P, IF
Target: COX4I1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG792
Application*: WB: 1:500~1:1000 IHC: 1:50~1:100 ELISA: 1:40000
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 550
Application*: ELISA, IF, IHC, WB
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 330
Application*: ELISA, IF, IHC, WB
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CAP553
Application*: FC, ICC, IHC, IP, WB
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CAP552
Application*: ELISA, FC, ICC, WB
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CAP551
Application*: ELISA, WB
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CAP550
Application*: WB
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 2D4
Application*: IF, IHC, WB
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG
Specificity: Goat, Hamster, Human, Monkey, Mouse, Rat
Clone: CAP549
Application*: FC, ICC, IP, WB
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CAP548
Application*: ICCFC, WB
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CAP547
Application*: WB
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CAP546
Application*: WB
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF111
Application*: ELISA, WB, IHC, IF, FC
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CB215A
Application*: ELISA, WB
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CB166
Application*: WB, IF/ICC
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: 4G11
Application*: WB, IHC-P, FC
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Hamster, Monkey, Goat
Clone: CBAb075
Application*: WB, IH, IC, IP, FC
Target: COX4I1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat
Clone: D6I4K
Application*: WB, IP, P
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Mouse
Clone: 4D2-4A10-8B8
Application*: WB, P, IF
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBCNC-303
Application*: FC, ICC, IH, IP, WB
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: GT854
Application*: IF, WB
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CT6C8
Application*: WB, IF
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBXC-2834
Application*: E, WB, IH, IF, F
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXC-2552
Application*: E, WB, IH, IF, F
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Rat
Clone: CBXC-2971
Application*: WB, IH, IF, P
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Monkey
Clone: CBXC-2992
Application*: WB, F, E, IF
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYY-C2951
Application*: WB, IF
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Monkey, Rat, Goat
Clone: CBYY-C2950
Application*: F, IF, IP, WB
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYY-C2926
Application*: E, WB
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: CBYY-C0701
Application*: WB, P, IF
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: CBYY-C0508
Application*: WB, IC
Target: COX4I1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBFYC-2117
Application*: WB
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Goat, Hamster, Human, Mouse, Rat
Clone: CBFYC-2115
Application*: F, IC, IP, WB
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Cattle, Human
Clone: CBFYC-2114
Application*: IF, IH, WB
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Cattle, Human, Mouse, Rat, Zebrafish
Clone: CBFYC-0437
Application*: WB
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat, Human, Monkey
Clone: 6B3
Application*: WB, E, C, F
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat, Mouse
Clone: 100A-6C8
Application*: WB
Target: COX4I1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Rat, Monkey, Zebrafish, Cattle, Pig
Clone: 3E11
Application*: WB, IP, P, C, IF, F
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Mouse, Rat, Hamster, Cattle, Human, Zebrafish
Clone: 20E8C12
Application*: WB, IP, C, P, C, F, IC/IF
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: 8D8
Application*: WB, P, IF(P)
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 854
Application*: WB, IC/IF
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: 673803
Application*: WB, IC
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 5B9
Application*: WB
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Hamster, Monkey
Clone: 4D11-B3-E8
Application*: WB, IF, F
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4A10
Application*: E, WB
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Dog, C. elegans, Goat, Hamster, Mollusca, Mouse, Sheep, Rat, Monkey, Zebrafish
Clone: 1D6E1A8
Application*: F, IC, IF, C, P, WB
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Hamster, Monkey, Mouse, Rat
Clone: 13k36
Application*: F, IC, IP, WB
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey, Mouse, Rat
Clone: 13B188
Application*: E, C, WB
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 15B133
Application*: F, IC, IP, WB
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 10G8D12C12
Application*: WB, P, C, F, IC/IF
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CF112
Application*: ELISA, WB, IHC, IF, FC
Target: COX4I1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Cattle, Human, Pig, Rat, Zebrafish
Clone: CBWJC-2974
Application*: F, IC, IF, C, P, IP, WB
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBWJC-2973
Application*: WB, IC
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Rat
Clone: GT6310
Application*: IC, IF, P, WB
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJC-2056
Application*: E, IC, IF, C, P, IP, WB
Target: COX4I1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBWJC-2055
Application*: WB, IP, P, F, IC
Target: COX4I1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Cattle
Clone: CBFYC-2113
Application*: IF, WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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