CORO1C

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq]

coronin, actin binding protein, 1C

Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (PubMed:25074804, PubMed:25925950).

Increases the presence of activated RAC1 at the leading edge of migrating cells (PubMed:25074804, PubMed:25925950).

Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments (By similarity).

Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460).

Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460).

Required for normal cell proliferation, cell migration, and normal formation of lamellipodia (By similarity).

Required for normal distribution of mitochondria within cells (By similarity).

Isoform 3:
Involved in myogenic differentiation.

Actin filament organization Source: GO_Central
Activation of GTPase activity Source: UniProtKB
Cell migration Source: GO_Central
Endosomal transport Source: UniProtKB
Endosome fission Source: UniProtKB
Endosome membrane tubulation Source: UniProtKB
Establishment of protein localization Source: UniProtKB
Membrane fission Source: UniProtKB
Negative regulation of epithelial cell migration Source: UniProtKB
Negative regulation of focal adhesion assembly Source: UniProtKB
Negative regulation of protein kinase activity by regulation of protein phosphorylation Source: UniProtKB
Negative regulation of protein phosphorylation Source: UniProtKB
Negative regulation of substrate adhesion-dependent cell spreading Source: UniProtKB
Neural crest cell migration Source: UniProtKB
Phagocytosis Source: ProtInc
Positive regulation of lamellipodium morphogenesis Source: UniProtKB
Regulation of epithelial cell migration Source: UniProtKB
Regulation of fibroblast migration Source: UniProtKB
Regulation of focal adhesion assembly Source: UniProtKB
Regulation of protein phosphorylation Source: UniProtKB
Regulation of ruffle assembly Source: Ensembl
Regulation of substrate adhesion-dependent cell spreading Source: UniProtKB
Signal transduction Source: ProtInc

Cytoskeleton; Endosome membrane; Cell membrane; Ruffle membrane; Lamellipodium; Cell cortex. All isoforms colocalize with the actin cytoskeleton in the cytosol, and especially in the cell cortex (PubMed:10828594, PubMed:19651142, PubMed:25074804). Colocalizes with F-actin at the leading edge of lamellipodia. Partially colocalizes with microtubules and vimentin intermediate filaments (PubMed:10828594, PubMed:19651142, PubMed:25074804). Localizes to endosome membrane tubules/buds (PubMed:30220460).
Isoform 3: Cytoskeleton; Sarcolemma; Cell membrane; Sarcomere; Synapse; Cell cortex. Colocalizes with the thin filaments of the sarcomere and with the postsynaptic area and the junctional sarcoplasm of motor end plates. Colocalizes with the actin cytoskeleton in the cytosol, and especially in the cell cortex.