COL6A1

COL6A1 (Collagen Type VI Alpha 1 Chain) is a Protein Coding gene. Diseases associated with COL6A1 include Bethlem Myopathy 1 and Ullrich Congenital Muscular Dystrophy 1. Among its related pathways are Integrin Pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include platelet-derived growth factor binding. An important paralog of this gene is COL6A2.

Full Name

Collagen Type VI Alpha 1 Chain

Function

Collagen VI acts as a cell-binding protein.

Biological Process

Cell adhesion Source: UniProtKB-KW
Cellular response to amino acid stimulus Source: Ensembl
Collagen fibril organization Source: Reactome
Endodermal cell differentiation Source: UniProtKB
Extracellular matrix organization Source: Reactome
Osteoblast differentiation Source: UniProtKB

Cellular Location

Extracellular matrix

Involvement in disease

Bethlem myopathy 1 (BTHLM1):
A benign proximal myopathy characterized by early childhood onset and joint contractures most frequently affecting the elbows and ankles.
Ullrich congenital muscular dystrophy 1 (UCMD1):
A congenital myopathy characterized by muscle weakness and multiple joint contractures, generally noted at birth or early infancy. The clinical course is more severe than in Bethlem myopathy.

PTM

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

Anti-COL6A1 antibodies

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-COL6A1 Recombinant Antibody (CBLC296-LY) (CBMAB-C11110-LY)

Datasheet

SDS

Target: COL6A1

Host: Mouse

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBLC296-LY

Application*: WB, IP, IF, E

Mouse Anti-COL6A1 Recombinant Antibody (VI-26) (CBMAB-C11111-LY)

Datasheet

SDS

Target: COL6A1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rabbit

Clone: VI-26

Application*: P, C, WB

Datasheet

SDS

Target: COL6A1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: EG776

Application*: IHC: 1:50~1:100 ELISA: 1:10000

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)