CHRNA5

The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).[provided by RefSeq, Jun 2010]

Cholinergic Receptor Nicotinic Alpha 5 Subunit

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Behavioral response to nicotine Source: UniProtKB
Chemical synaptic transmission Source: GO_Central
Ion transmembrane transport Source: GO_Central
Nervous system process Source: GO_Central
Regulation of membrane potential Source: GO_Central
Regulation of synaptic vesicle exocytosis Source: Ensembl
Response to nicotine Source: GO_Central
Signal transduction Source: GO_Central
Synaptic transmission, cholinergic Source: GO_Central

Postsynaptic cell membrane; Cell membrane

Extracellular: 23-254
Helical: 255-275
Helical: 282-302
Helical: 317-337
Cytoplasmic: 338-429
Helical: 430-451
Extracellular: 452-468