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CERS2

This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

Full Name

Ceramide Synthase 2

Function

Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward very-long (C22:0-C24:0) chain as acyl donor. May regulate lipid metabolism in hepatocytes (By similarity).

Biological Process

Ceramide biosynthetic process Source: UniProtKB
Negative regulation of axon regeneration Source: BHF-UCL
Negative regulation of Schwann cell migration Source: BHF-UCL
Negative regulation of Schwann cell proliferation involved in axon regeneration Source: BHF-UCL
Regulation of lipid metabolic process Source: UniProtKB
Sphingolipid biosynthetic process Source: Reactome

Cellular Location

Endoplasmic reticulum membrane

Topology

Lumenal: 1-40
Helical: 41-61
Helical: 140-160
Helical: 181-201
Helical: 209-229
Helical: 264-284
Helical: 304-324
Cytoplasmic: 325-380

PTM

Acetylated. Deacetylation by SIRT3 increases enzyme activity and promotes mitochondrial ceramide accumulation.
Phosphorylated at the C-terminus by CK2, leading to increase the ceramide synthase activity.

Anti-CERS2 antibodies

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-CERS2 Recombinant Antibody (CBYJL-093) (CBMAB-L0149-YJ)

SDS

Target: CERS2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYJL-093

Application*: E, WB

Mouse Anti-CERS2 Recombinant Antibody (CBYJL-092) (CBMAB-L0148-YJ)

SDS

Target: CERS2

Host: Mouse

Antibody Isotype: IgM, κ

Specificity: Human, Mouse

Clone: CBYJL-092

Application*: E, WB, IH

Mouse Anti-CERS2 Recombinant Antibody (CBYJL-091) (CBMAB-L0147-YJ)

SDS

Target: CERS2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Zebrafish

Clone: CBYJL-091

Application*: WB, IH, IF

Rabbit Anti-CERS2 Recombinant Antibody (CBYJL-090) (CBMAB-L0146-YJ)

SDS

Target: CERS2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJL-090

Application*: WB, IH, IF

Mouse Anti-CERS2 Recombinant Antibody (CBYJL-089) (CBMAB-L0145-YJ)

SDS

Target: CERS2

Host: Mouse

Antibody Isotype: IgM

Specificity: Human

Clone: CBYJL-089

Application*: WB, IP, IF, E

Mouse Anti-CERS2 Recombinant Antibody (CBYJL-087) (CBMAB-L0143-YJ)

SDS

Target: CERS2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat, Horse, Dog

Clone: CBYJL-087

Application*: WB, IP, IF, E, P

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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