CD79B

CD79B (CD79b Molecule) is a Protein Coding gene. Diseases associated with CD79B include Agammaglobulinemia 6, Autosomal Recessive and Agammaglobulinemia, Non-Bruton Type. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Innate Immune System. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity.

Full Name

CD79b Molecule

Function

Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.

Biological Process

Adaptive immune response Source: UniProtKB-KW
B cell differentiation Source: GO_Central
B cell receptor signaling pathway Source: GO_Central
Immune response Source: ProtInc
Signal transduction Source: ProtInc

Cellular Location

Cell membrane. Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.

Involvement in disease

Agammaglobulinemia 6, autosomal recessive (AGM6): A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.

Topology

Extracellular: 29-159
Helical: 160-180
Cytoplasmic: 181-229

PTM

Phosphorylated on tyrosine upon B-cell activation by SRC-type Tyr-kinases such as BLK, LYN and SYK.

Anti-CD79B antibodies

Rabbit Anti-CD79B Recombinant Antibody (CP0226) (CBMAB-CP0226-LY)

Datasheet

SDS

Target: CD79B

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: CP0226

Application*: E

Rabbit Anti-CD79B Recombinant Antibody (C10618) (CBMAB-C10618-LY)

Datasheet

SDS

Target: CD79B

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: C10618

Application*: P

Mouse Anti-CD79B Recombinant Antibody (CBYY-C0512) (CBMAB-C1530-YY)

Datasheet

SDS

Target: CD79B

Host: Mouse

Antibody Isotype: IgM, κ

Specificity: Human, Mouse, Rat, Dog, Cattle, Pig

Clone: CBYY-C0512

Application*: E, IF, IP, WB

Mouse Anti-CD79B Recombinant Antibody (4E10-2A10) (CBMAB-C6834-LY)

Datasheet

SDS

Target: CD79B

Host: Mouse

Antibody Isotype: IgG1, κ

Datasheet

SDS

Target: CD79B

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBFYC-1425

Application*: F, IC

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)