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CD79B

CD79B (CD79b Molecule) is a Protein Coding gene. Diseases associated with CD79B include Agammaglobulinemia 6, Autosomal Recessive and Agammaglobulinemia, Non-Bruton Type. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Innate Immune System. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity.
Full Name
CD79b Molecule
Function
Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.
Biological Process
Adaptive immune response Source: UniProtKB-KW
B cell differentiation Source: GO_Central
B cell receptor signaling pathway Source: GO_Central
Immune response Source: ProtInc
Signal transduction Source: ProtInc
Cellular Location
Cell membrane. Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.
Involvement in disease
Agammaglobulinemia 6, autosomal recessive (AGM6): A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.
Topology
Extracellular: 29-159
Helical: 160-180
Cytoplasmic: 181-229
PTM
Phosphorylated on tyrosine upon B-cell activation by SRC-type Tyr-kinases such as BLK, LYN and SYK.

Anti-CD79B antibodies

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Target: CD79B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CP0226
Application*: E
Target: CD79B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: C10618
Application*: P
Target: CD79B
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human, Mouse, Rat, Dog, Cattle, Pig
Clone: CBYY-C0512
Application*: E, IF, IP, WB
Target: CD79B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4E10-2A10
Application*: E, IP, WB
Target: CD79B
Host: Mouse
Antibody Isotype: IgG2b, λ
Specificity: Human, Mouse, Rat, Horse, Pig
Clone: CBXC-0268
Application*: P, IF, IP, WB
Target: CD79B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXC-1283
Application*: F, IP, WB
Target: CD79B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: C0416
Application*: E, IF, IP, WB
Target: CD79B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-C0438
Application*: IF, IP, WB, F
Target: CD79B
Host: Rat
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBYY-C0140
Application*: F, IP, WB
Target: CD79B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBYY-C0139
Application*: E, IF, IP, WB
Target: CD79B
Host: Armenian Hamster
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBFYC-1426
Application*: E, IF, IP, WB, F
Target: CD79B
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYC-1425
Application*: F, IC
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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