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Rat Anti-CD79B Recombinant Antibody (CBFYC-1425) (CBMAB-C1483-FY)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBFYC-1425
Antibody Isotype
IgG2a
Application
FC, ICC

Basic Information

Immunogen
Recombinant mouse CD79B (Met29-Asp158).
Host Species
Rat
Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IF(ICC)8-25 µg/ml
FC2.5 µg /10^6 Cells

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CD79b Molecule
Introduction
CD79B (CD79b Molecule) is a Protein Coding gene. Diseases associated with CD79B include Agammaglobulinemia 6, Autosomal Recessive and Agammaglobulinemia, Non-Bruton Type. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Innate Immune System. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity.
Entrez Gene ID
15985
UniProt ID
P15530
Alternative Names
B29; Igb; Igbeta; Ig-beta
Function
Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.
Biological Process
Adaptive immune response Source: UniProtKB-KW
B cell differentiation Source: GO_Central
B cell receptor signaling pathway Source: GO_Central
Immune response Source: ProtInc
Signal transduction Source: ProtInc
Cellular Location
Cell membrane. Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.
Involvement in disease
Agammaglobulinemia 6, autosomal recessive (AGM6): A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.
Topology
Extracellular: 29-159
Helical: 160-180
Cytoplasmic: 181-229
PTM
Phosphorylated on tyrosine upon B-cell activation by SRC-type Tyr-kinases such as BLK, LYN and SYK.
More Infomation

Cheng, G. F., Kong, W. G., Zhai, X., Mu, Q. J., Dong, Z. R., Zhan, M. T., & Xu, Z. (2021). Molecular cloning and expression analysis of CD79a and CD79b in rainbow trout (Oncorhynchus mykiss) after bacterial, parasitic, and viral infection. Fish & Shellfish Immunology, 118, 385-395.

Camus, V., & Tilly, H. (2020). Polatuzumab vedotin, an anti-CD79b antibody–drug conjugate for the treatment of relapsed/refractory diffuse large B-cell lymphoma. Future Oncology, 17(2), 127-135.

Bourbon, E., & Salles, G. (2020). Polatuzumab vedotin: an investigational anti-CD79b antibody drug conjugate for the treatment of diffuse large B-cell lymphoma. Expert Opinion on Investigational Drugs, 29(10), 1079-1088.

Ding, S., Mao, X., Cao, Y., Wang, N., Xu, H., & Zhou, J. (2020). Targeting CD79b for chimeric antigen receptor T-cell therapy of B-cell lymphomas. Targeted Oncology, 15, 365-375.

Li, D., Lee, D., Dere, R. C., Zheng, B., Yu, S. F., Fuh, F. K., ... & Prabhu, S. (2019). Evaluation and use of an anti‐cynomolgus monkey CD79b surrogate antibody–drug conjugate to enable clinical development of polatuzumab vedotin. British journal of pharmacology, 176(19), 3805-3818.

Schrader, A. M., Jansen, P. M., Willemze, R., Vermeer, M. H., Cleton-Jansen, A. M., Somers, S. F., ... & Vermaat, J. S. (2018). High prevalence of MYD88 and CD79B mutations in intravascular large B-cell lymphoma. Blood, The Journal of the American Society of Hematology, 131(18), 2086-2089.

Li, H., Li, Y., Zhang, X., Wang, Y., Zhang, W., Wu, X., & Wang, Z. (2017). Molecular characterization of the CD79a and CD79b and its role against Aeromonas hydrophila infection in Chinese sucker (Myxocyprinus asiaticus). Fish physiology and biochemistry, 43(6), 1571-1585.

Chen, W., Shankar, S., Lohr, J., Yao, X. T., Li, H., Chen, X., ... & Wigginton, J. (2017). SAT0027 Immunomodulatory effects of MGD010, a dart® molecule targeting human B-CELL CD32B and CD79B.

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For research use only. Not intended for any clinical use.

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