CD3E

CD3E (CD3e Molecule) is a Protein Coding gene. Diseases associated with CD3E include Immunodeficiency 18 and T-B+ Severe Combined Immunodeficiency Due To Cd3delta/Cd3epsilon/Cd3zeta. Among its related pathways are G-protein signaling N-RAS regulation pathway and Toll-like receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and signal transducer activity.

CD3e Molecule

CD3e Molecule; CD3e Antigen, Epsilon Polypeptide (TiT3 Complex); T-Cell Surface Antigen T3/Leu-4 Epsilon Chain; CD3e Molecule, Epsilon (CD3-TCR Complex); T3E; T-Cell Antigen Receptor Complex, Epsilon Subunit Of T3;

Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098).
In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region (PubMed:10384095, PubMed:26507128).

Adaptive immune response Source: UniProtKB-KW
Apoptotic signaling pathway Source: Ensembl
Cell surface receptor signaling pathway Source: GO_Central
Cerebellum development Source: Ensembl
Dendrite development Source: Ensembl
G protein-coupled receptor signaling pathway Source: ProtInc
Negative regulation of gene expression Source: UniProtKB
Negative regulation of smoothened signaling pathway Source: Ensembl
Negative thymic T cell selection Source: Ensembl
Positive regulation of alpha-beta T cell proliferation Source: Ensembl
Positive regulation of calcium-mediated signaling Source: Ensembl
Positive regulation of cell-cell adhesion mediated by integrin Source: BHF-UCL
Positive regulation of cell-matrix adhesion Source: BHF-UCL
Positive regulation of gene expression Source: UniProtKB
Positive regulation of interferon-gamma production Source: Ensembl
Positive regulation of interleukin-2 production Source: Ensembl
Positive regulation of interleukin-4 production Source: Ensembl
Positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
Positive regulation of T cell anergy Source: Ensembl
Positive regulation of T cell proliferation Source: UniProtKB
Positive thymic T cell selection Source: GO_Central
Protein-containing complex assembly Source: UniProtKB
Regulation of apoptotic process Source: UniProtKB
Regulation of immune response Source: Reactome
Response to nutrient Source: Ensembl
Signal complex assembly Source: ProtInc
T cell activation Source: UniProtKB
T cell costimulation Source: Ensembl
T cell receptor signaling pathway Source: Reactome
Transmembrane receptor protein tyrosine kinase signaling pathway Source: ProtInc

Cell membrane

Immunodeficiency 18 (IMD18): An autosomal recessive primary immunodeficiency characterized by onset in infancy or early childhood of recurrent infections. The severity is variable, encompassing both a mild immunodeficiency and severe combined immunodeficiency (SCID), resulting in early death without bone marrow transplantation in some patients. Immunologic work-up of the IMD18 SCID patients shows a T cell-negative, B cell-positive, natural killer (NK) cell-positive phenotype, whereas T-cell development is not impaired in the mild form of IMD18.

Extracellular: 23-126
Helical: 127-152
Cytoplasmic: 153-207

Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.