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CCR5

CCR5 (C-C Motif Chemokine Receptor 5 (Gene/Pseudogene)) is a Protein Coding gene. Diseases associated with CCR5 include West Nile Virus and Diabetes Mellitus, Insulin-Dependent, 22. Among its related pathways are Cytokine Signaling in Immune system and Akt Signaling. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and phosphatidylinositol phospholipase C activity. An important paralog of this gene is CCR2.
Full Name
C-C Motif Chemokine Receptor 5 (Gene/Pseudogene)
Alternative Names
C-C Motif Chemokine Receptor 5 (Gene/Pseudogene); Chemokine (C-C Motif) Receptor 5; HIV-1 Fusion Coreceptor; CC-CKR-5; ChemR13; CMKBR5; CCR-5; Chemokine (C-C Motif) Receptor 5 (Gene/Pseudogene); C-C Motif Chemokine Receptor 5 A159A; Chemokine Recptor CCR5 Delta32;
Function
Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor (PubMed:30713770).
(Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) of human immunodeficiency virus-1/HIV-1.
Biological Process
Calcium ion transport Source: UniProtKB
Calcium-mediated signaling Source: UniProtKB
Cell-cell signaling Source: UniProtKB
Cell chemotaxis Source: GO_Central
Cell surface receptor signaling pathway Source: ProtInc
Cellular defense response Source: ProtInc
Cellular response to lipopolysaccharide Source: UniProtKB
Chemotaxis Source: ProtInc
Cytokine-mediated signaling pathway Source: Reactome
Dendritic cell chemotaxis Source: BHF-UCL
Entry into host Source: Reactome
Fusion of virus membrane with host plasma membrane Source: Reactome
G protein-coupled receptor signaling pathway Source: UniProtKB
Immune response Source: GO_Central
Inflammatory response Source: GO_Central
MAPK cascade Source: UniProtKB
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: UniProtKB
Response to cholesterol Source: UniProtKB
Signaling Source: UniProtKB
Cellular Location
Cell membrane
Involvement in disease
Diabetes mellitus, insulin-dependent, 22 (IDDM22): A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Topology
Extracellular: 1-30
Helical: 31-58
Cytoplasmic: 59-68
Helical: 69-89
Extracellular: 90-102
Helical: 103-124
Cytoplasmic: 125-141
Helical: 142-166
Extracellular: 167-198
Helical: 199-218
Cytoplasmic: 219-235
Helical: 236-260
Extracellular: 261-277
Helical: 278-301
Cytoplasmic: 302-352
PTM
Sulfated on at least 2 of the N-terminal tyrosines. Sulfation contributes to the efficiency of HIV-1 entry and is required for efficient binding of the chemokines, CCL3 and CCL4.
O-glycosylated, but not N-glycosylated. Ser-6 appears to be the major site. Also sialylated glycans present which contribute to chemokine binding. Thr-16 and Ser-17 may also be glycosylated and, if so, with small moieties such as a T-antigen.
Palmitoylation in the C-terminal is important for cell surface expression, and to a lesser extent, for HIV entry.
Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines especially by APO-RANTES.

Anti-CCR5 antibodies

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Target: CCR5
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: AG03
Application*: F, IC, In Vivo
Target: CCR5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: E164
Application*: WB, IF, E
Target: CCR5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: R-C10
Application*: WB, IF, IP
Target: CCR5
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYY-C0171
Application*: WB
Target: CCR5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-1078
Application*: P, IP, IF, WB, F
Target: CCR5
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBFYC-1077
Application*: F
Target: CCR5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYC-0252
Application*: E, IP, IF, WB
Target: CCR5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYM-0966
Application*: E, IP, IF, WB
Target: CCR5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: T218
Application*: WB, IF, IP, F
Target: CCR5
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: HEK/1/85a
Application*: F
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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