CCR2

CCR2 (C-C Motif Chemokine Receptor 2) is a Protein Coding gene. Diseases associated with CCR2 include Idiopathic Anterior Uveitis and Cd3zeta Deficiency. Among its related pathways are Cytokine Signaling in Immune system and Defensins. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and chemokine receptor activity. An important paralog of this gene is CCR5.

C-C Motif Chemokine Receptor 2

Key functional receptor for CCL2 but can also bind CCL7 and CCL12 (PubMed:8146186, PubMed:8048929, PubMed:23408426).
Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (Probable). Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B (PubMed:23938203).
Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation (By similarity).
Facilitates the export of mature thymocytes by enhancing directional movement of thymocytes to sphingosine-1-phosphate stimulation and up-regulation of S1P1R expression; signals through the JAK-STAT pathway to regulate FOXO1 activity leading to an increased expression of S1P1R (By similarity).
Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity).
Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity).
Mediates the recruitment of macrophages and monocytes to the injury site following brain injury (By similarity).
(Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection.

Blood vessel remodeling Source: BHF-UCL
Calcium-mediated signaling Source: GO_Central
Cell chemotaxis Source: GO_Central
Cellular calcium ion homeostasis Source: BHF-UCL
Cellular defense response Source: ProtInc
Cellular homeostasis Source: BHF-UCL
Chemokine-mediated signaling pathway Source: BHF-UCL
Chemotaxis Source: ProtInc
Cytokine-mediated signaling pathway Source: MGI
Dendritic cell chemotaxis Source: BHF-UCL
G protein-coupled receptor signaling pathway Source: Reactome
Immune response Source: GO_Central
Inflammatory response Source: GO_Central
Inflammatory response to wounding Source: UniProtKB
Macrophage migration Source: UniProtKB
Monocyte extravasation Source: UniProtKB
Negative regulation of adenylate cyclase activity Source: ProtInc
Negative regulation of angiogenesis Source: BHF-UCL
Negative regulation of eosinophil degranulation Source: BHF-UCL
Negative regulation of type 2 immune response Source: BHF-UCL
Positive regulation of alpha-beta T cell proliferation Source: BHF-UCL
Positive regulation of astrocyte chemotaxis Source: BHF-UCL
Positive regulation of CD8-positive, alpha-beta T cell extravasation Source: BHF-UCL
Positive regulation of cold-induced thermogenesis Source: YuBioLab
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Positive regulation of hematopoietic stem cell migration Source: BHF-UCL
Positive regulation of immune complex clearance by monocytes and macrophages Source: BHF-UCL
Positive regulation of inflammatory response Source: BHF-UCL
Positive regulation of interferon-gamma production Source: BHF-UCL
Positive regulation of interleukin-2 production Source: BHF-UCL
Positive regulation of monocyte chemotaxis Source: UniProtKB
Positive regulation of monocyte extravasation Source: BHF-UCL
Positive regulation of NMDA glutamate receptor activity Source: ARUK-UCL
Positive regulation of synaptic transmission, glutamatergic Source: UniProtKB
Positive regulation of T cell activation Source: BHF-UCL
Positive regulation of T cell chemotaxis Source: BHF-UCL
Positive regulation of T-helper 1 type immune response Source: BHF-UCL
Positive regulation of thymocyte migration Source: UniProtKB
Positive regulation of tumor necrosis factor production Source: BHF-UCL
Receptor signaling pathway via JAK-STAT Source: ProtInc
Regulation of inflammatory response Source: UniProtKB
Regulation of T cell cytokine production Source: UniProtKB
Regulation of T cell differentiation Source: UniProtKB
Regulation of vascular endothelial growth factor production Source: BHF-UCL
Response to wounding Source: ProtInc
Sensory perception of pain Source: UniProtKB
T-helper 17 cell chemotaxis Source: BHF-UCL
Viral process Source: UniProtKB-KW

Cell membrane. The chemoattractant receptors are distributed throughout the cell surface; after stimulation with a ligand, such as CCL2, they are rapidly recruited into microdomain clusters at the cell membrane.

Extracellular: 1-42
Helical: 43-70
Cytoplasmic: 71-80
Helical: 81-100
Extracellular: 101-114
Helical: 115-136
Cytoplasmic: 137-153
Helical: 154-178
Extracellular: 179-206
Helical: 207-226
Cytoplasmic: 227-243
Helical: 244-268
Extracellular: 269-285
Helical: 286-309
Cytoplasmic: 310-374

N-glycosylated.
Sulfation increases the affinity for both monomeric and dimeric CCL2 with stronger binding to the monomeric form (PubMed:11046064, PubMed:23408426). Binding of sulfated CCR2 to CCL2 promotes conversion of CCL2 from dimer to monomer (PubMed:11046064, PubMed:23408426).