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BSG

The protein encoded by this gene is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. The encoded protein is also a member of the immunoglobulin superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Full Name
Basigin (Ok Blood Group)
Function
Isoform 1: Essential for normal retinal maturation and development (By similarity).
Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors (PubMed:25957687).
In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (PubMed:25957687).
May act as a potent stimulator of IL6 secretion in multiple cell lines that include monocytes (PubMed:21620857).
Isoform 2: Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells (PubMed:11943775, PubMed:11688976).
Plays an important role in targeting monocarboxylate transporters SLC16A1/GLUT1, SLC16A11 and SLC16A12 to the plasma membrane (PubMed:17127621, PubMed:21778275, PubMed:28666119).
Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling (PubMed:25825981).
Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA (isoform VEGF-165 and VEGF-121) and KDR/VEGFR2 in endothelial cells (PubMed:19837976).
Plays a key role in regulating tumor growth, invasion, metastasis and neoangiogenesis by stimulating the production and release of extracellular matrix metalloproteinases and KDR/VEGFR2 by both tumor cells and stromal cells (fibroblasts and endothelial cells) (PubMed:12553375, PubMed:11992541, PubMed:15833850).
Isoform 1: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7 and Dd2.
Isoform 2: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7, Dd2, 7G8 and HB3 (PubMed:22080952, PubMed:26195724).
Binding of P.falciparum RH5 results in BSG dimerization which triggers an increase in intracellular Ca2+ in the erythrocyte (PubMed:28409866).
This essential step leads to a rearrangement of the erythrocyte cytoskeleton required for the merozoite invasion (PubMed:28409866). Can facilitate human SARS coronavirus (SARS-CoV-1) infection via its interaction with virus-associated PPIA/CYPA. Can facilitate HIV-1 infection via its interaction with virus-associated PPIA/CYPA. First described as a receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it is not required for SARS-CoV-2 infection. Acts as a receptor for measles virus. Promotes entry of pentamer-expressing human cytomegalovirus (HCMV) into epithelial and endothelial cells.
Biological Process
Angiogenesis Source: UniProtKB-KW
Axon guidance Source: GO_Central
Cell surface receptor signaling pathway Source: ProtInc
Decidualization Source: Ensembl
Dendrite self-avoidance Source: GO_Central
Embryo implantation Source: Ensembl
Endothelial tube morphogenesis Source: UniProtKB
Extracellular matrix disassembly Source: Reactome
Extracellular matrix organization Source: Reactome
Homophilic cell adhesion via plasma membrane adhesion molecules Source: GO_Central
Leukocyte migration Source: Reactome
Neural retina development Source: UniProtKB
Neutrophil chemotaxis Source: UniProtKB
Odontogenesis of dentin-containing tooth Source: Ensembl
Photoreceptor cell maintenance Source: UniProtKB
Positive regulation of endothelial cell migration Source: UniProtKB
Positive regulation of interleukin-6 production Source: UniProtKB
Positive regulation of matrix metallopeptidase secretion Source: UniProtKB
Positive regulation of vascular endothelial growth factor production Source: UniProtKB
Positive regulation of viral entry into host cell Source: UniProtKB
Protein localization to plasma membrane Source: ARUK-UCL
Pyruvate metabolic process Source: Reactome
Response to cAMP Source: Ensembl
Response to mercury ion Source: Ensembl
Response to peptide hormone Source: Ensembl
Cellular Location
Endoplasmic reticulum membrane; Endosome; Extracellular exosome; Golgi membrane; Mitochondrion; Basolateral plasma membrane; Integral component of plasma membrane; Plasma membrane; Sarcolemma; Acrosomal membrane; Axon; Focal adhesion; Intracellular membrane-bounded organelle; Melanosome; Membrane; Membrane raft; Photoreceptor inner segment; Photoreceptor outer segment
Topology
Extracellular: 138-323 aa
Helical: 324-344 aa
Cytoplasmic: 345-385 aa
PTM
N-glycosylated.

Anti-BSG antibodies

+ Filters
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Target: BSG
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: RL73
Application*: FC, IP, WB, IH, IF
Target: BSG
Host: Rat
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: OX114
Application*: FC, IH, IF
Target: BSG
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYY-0843
Application*: E, IF
Target: BSG
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBYY-0836
Application*: WB, E
Target: BSG
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Mouse, Rat
Clone: CBYY-0829
Application*: WB, IP, IF, E
Target: BSG
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-0822
Application*: WB, IP, IF, FC
Target: BSG
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Cattle
Clone: CBYY-0818
Application*: WB, IP, IF, E
Target: BSG
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYE-0317
Application*: FC, IP, WB, IH, IF
Target: BSG
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBFYE-0315
Application*: WB, IP, IF, E
Target: BSG
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 8D6
Application*: FC, IF, P, IP, WB
Target: BSG
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: MEM-M6/1
Application*: FC, IP, WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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