BCL2L11

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013]

BCL2 Like 11

Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.

Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Apoptotic process Source: UniProtKB
Apoptotic process involved in embryonic digit morphogenesis Source: Ensembl
B cell apoptotic process Source: Ensembl
B cell homeostasis Source: Ensembl
Brain development Source: Ensembl
Cell-matrix adhesion Source: Ensembl
Cellular response to amyloid-beta Source: Ensembl
Cellular response to estradiol stimulus Source: Ensembl
Cellular response to glucocorticoid stimulus Source: ARUK-UCL
Cytokine-mediated signaling pathway Source: Reactome
Developmental pigmentation Source: Ensembl
Ear development Source: Ensembl
Extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
Intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
In utero embryonic development Source: Ensembl
Kidney development Source: Ensembl
Male gonad development Source: Ensembl
Mammary gland development Source: Ensembl
Meiosis I Source: GO_Central
Myeloid cell homeostasis Source: Ensembl
Odontogenesis of dentin-containing tooth Source: Ensembl
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of apoptotic process by virus Source: Ensembl
Positive regulation of autophagy in response to ER overload Source: Ensembl
Positive regulation of cell cycle Source: Ensembl
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Source: ParkinsonsUK-UCL
Positive regulation of fibroblast apoptotic process Source: UniProtKB
Positive regulation of intrinsic apoptotic signaling pathway Source: UniProtKB
Positive regulation of IRE1-mediated unfolded protein response Source: ParkinsonsUK-UCL
Positive regulation of neuron apoptotic process Source: Ensembl
Positive regulation of protein-containing complex assembly Source: BHF-UCL
Positive regulation of release of cytochrome c from mitochondria Source: UniProtKB
Post-embryonic animal organ morphogenesis Source: Ensembl
Protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Source: Reactome
Regulation of apoptotic process Source: ARUK-UCL
Regulation of developmental pigmentation Source: Ensembl
Regulation of organ growth Source: Ensembl
Response to endoplasmic reticulum stress Source: UniProtKB
Spermatogenesis Source: Ensembl
Spleen development Source: Ensembl
T cell homeostasis Source: Ensembl
Thymocyte apoptotic process Source: Ensembl
Thymus development Source: Ensembl
Tube formation Source: Ensembl

Endomembrane system. Associated with intracytoplasmic membranes.
Isoform BimEL: Mitochondrion. Translocates from microtubules to mitochondria on loss of cell adherence.
Isoform BimL: Mitochondrion.
Isoform BimS: Mitochondrion
Isoform Bim-alpha1: Mitochondrion

Phosphorylation at Ser-69 by MAPK1/MAPK3 leads to interaction with TRIM2 and polyubiquitination, followed by proteasomal degradation (PubMed:15486195, PubMed:21478148). Deubiquitination catalyzed by USP27X stabilizes the protein (By similarity).
Ubiquitination by TRIM2 following phosphorylation by MAPK1/MAPK3 leads to proteasomal degradation. Conversely, deubiquitination catalyzed by USP27X stabilizes the protein.