AQP5

Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions. AQP0, AQ

Full Name

Aquaporin 5

Function

Forms a water-specific channel (PubMed:8621489, PubMed:18768791).
Plays an important role in fluid secretion in salivary glands (By similarity).
Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells (PubMed:16571723).
Seems to play a redundant role in water transport in the eye, lung and in sweat glands (By similarity).

Biological Process

Camera-type eye morphogenesis Source: Ensembl
Carbon dioxide transport Source: UniProtKB
Cellular hypotonic response Source: UniProtKB
Odontogenesis Source: UniProtKB
Pancreatic juice secretion Source: UniProtKB
Protein homotetramerization Source: UniProtKB
Saliva secretion Source: Ensembl
Water transport Source: UniProtKB

Cellular Location

Apical cell membrane; Cell membrane; Cytoplasmic vesicle membrane. Hypotonicity increases location at the cell membrane. Phosphorylation decreases location at the cell membrane.

Involvement in disease

Keratoderma, palmoplantar, Bothnian type (PPKB): A dermatological disorder characterized by diffuse non-epidermolytic hyperkeratosis of the skin of palms and soles. PPKB is frequently complicated by fungal infections.

Topology

Cytoplasmic: 1-12 aa
Helical: 13-33 aa
Extracellular: 34-39 aa
Helical: 40-60 aa
Cytoplasmic: 61-65 aa
Discontinuously helical: 66-74 aa
Cytoplasmic: 75-87 aa
Helical: 88-108 aa
Extracellular: 109-126 aa
Helical: 127-147 aa
Cytoplasmic: 148-158 aa
Helical: 159-179 aa
Extracellular: 180 aa
Discontinuously helical: 181-191 aa
Extracellular: 192-203 aa
Helical: 204-224 aa
Cytoplasmic: 225-265 aa

Anti-AQP5 antibodies

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Rabbit Anti-AQP5 Recombinant Antibody (CBYC-A725) (CBMAB-A3366-YC)

Datasheet

SDS

Target: AQP5

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBYC-A725

Application*: IC, IF, IH, WB

Mouse Anti-AQP5 Recombinant Antibody (D-7) (CBMAB-A3365-YC)

Datasheet

SDS

Target: AQP5

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: D-7

Application*: WB, IP, IF, E, P

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)