AGER

The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011]

Advanced Glycosylation End-Product Specific Receptor

Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.

Astrocyte activation
Cell surface receptor signaling pathway
Cellular response to amyloid-beta
Glucose mediated signaling pathway
Induction of positive chemotaxis
Inflammatory response
Innate immune response
Learning or memory
Microglial cell activation
Modulation of age-related behavioral decline
Negative regulation of blood circulation
Negative regulation of connective tissue replacement involved in inflammatory response wound healing
Negative regulation of interleukin-10 production
Negative regulation of long-term synaptic depression
Negative regulation of long-term synaptic potentiation
Neuron projection development
Positive regulation of activated T cell proliferation
Positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
Positive regulation of chemokine production
Positive regulation of dendritic cell differentiation
Positive regulation of endothelin production
Positive regulation of ERK1 and ERK2 cascade
Positive regulation of heterotypic cell-cell adhesion
Positive regulation of interleukin-12 production
Positive regulation of interleukin-1 beta production
Positive regulation of interleukin-6 production
Positive regulation of JNK cascade
Positive regulation of JUN kinase activity
Positive regulation of monocyte chemotactic protein-1 production
Positive regulation of monocyte extravasation
Positive regulation of NF-kappaB transcription factor activity
Positive regulation of NIK/NF-kappaB signaling
Positive regulation of p38MAPK cascade
Positive regulation of protein phosphorylation
Positive regulation of tumor necrosis factor production
Protein localization to membrane
Regulation of CD4-positive, alpha-beta T cell activation
Regulation of DNA binding
Regulation of inflammatory response
Regulation of long-term synaptic potentiation
Regulation of NIK/NF-kappaB signaling
Regulation of p38MAPK cascade
Regulation of spontaneous synaptic transmission
Regulation of synaptic plasticity
Regulation of T cell mediated cytotoxicity
Response to amyloid-beta
Response to hypoxia
Response to wounding
Transcytosis
Transport across blood-brain barrier

Isoform 1: Cell membrane
Isoform 2: Secreted
Isoform 10: Cell membrane

Extracellular: 23-342 aa
Helical: 343-363 aa
Cytoplasmic: 364-404 aa