ADAM32

This gene encodes a member of the disintegrin family of membrane-anchored proteins that play a role in diverse biological processes such as brain development, fertilization, tumor development and inflammation. This gene is predominantly expressed in the testis. The encoded protein undergoes proteolytic processing to generate a mature polypeptide comprised of an metalloprotease, disintegrin and epidermal growth factor-like domains. This gene is located in a cluster of other disintegrin and metallopeptidase family genes on chromosome 8. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

ADAM Metallopeptidase Domain 32

May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein.

Binding of sperm to zona pellucida
Cell adhesion

Membrane

Extracellular: 175-682 aa
Helical: 683-703 aa
Cytoplasmic: 704-787 aa