ADAM22

ADAM22 is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involvi

ADAM Metallopeptidase Domain 22

Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1.

Adult locomotory behavior
Cell adhesion
Central nervous system development
Myelination in peripheral nervous system
Negative regulation of cell adhesion
Neurotransmitter receptor localization to postsynaptic specialization membrane

Cell membrane; Axon

Developmental and epileptic encephalopathy 61 (DEE61): A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE61 is an autosomal recessive condition characterized by onset of seizures in infancy.

Extracellular: 223-736 aa
Helical: 737-757 aa
Cytoplasmic: 758-906 aa

The precursor is cleaved by a furin endopeptidase.