ADAM12

This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. [provided by RefSeq, Jan 2014]

ADAM Metallopeptidase Domain 12

Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity).

Cell adhesion
Extracellular matrix organization
Myoblast fusion
Positive regulation of angiogenesis

Isoform 1: Cell membrane
Isoform 2: Secreted
Isoform 3: Secreted
Isoform 4: Secreted

Extracellular: 208-708 aa
Helical: 709-729 aa
Cytoplasmic: 730-909 aa

The precursor is cleaved by a furin endopeptidase.