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ADAM12

This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. [provided by RefSeq, Jan 2014]
Full Name
ADAM Metallopeptidase Domain 12
Function
Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity).
Biological Process
Cell adhesion
Extracellular matrix organization
Myoblast fusion
Positive regulation of angiogenesis
Cellular Location
Isoform 1: Cell membrane
Isoform 2: Secreted
Isoform 3: Secreted
Isoform 4: Secreted
Topology
Extracellular: 208-708 aa
Helical: 709-729 aa
Cytoplasmic: 730-909 aa
PTM
The precursor is cleaved by a furin endopeptidase.

Anti-ADAM12 antibodies

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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)
Target: ADAM12
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: V2-179754
Application*: WB
Target: ADAM12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-179753
Application*: E, WB
Target: ADAM12
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: V2-179752
Application*: E, WB, IP
Target: ADAM12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-179751
Application*: IP
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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