ACOT7

This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been characterized. [provided by RefSeq, Jul 2008]

Acyl-CoA Thioesterase 7

Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Acyl-coenzyme A thioesterase 7/ACOT7 preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18. May play an important physiological function in brain.

Acyl-CoA metabolic process
Coenzyme A biosynthetic process
Fatty acid metabolic process
Long-chain fatty-acyl-CoA catabolic process
Medium-chain fatty acid biosynthetic process
Medium-chain fatty-acyl-CoA catabolic process
Palmitic acid biosynthetic process

Isoform 1: Mitochondrion
Isoform 4: Cytosol
Isoform 5: Mitochondrion
Isoform 6: Cytosol