ABCC4

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions. Alternative splicing results in multiple splice variants encoding different isoforms. [provided by RefSeq]

ATP-binding cassette, sub-family C (CFTR/MRP), member 4

ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules. Confers resistance to anticancer agents such as methotrexate.

Bile acid and bile salt transport
Bile acid signaling pathway
cAMP transport
Cilium assembly
Export across plasma membrane
Leukotriene transport
Platelet degranulation
Positive regulation of smooth muscle cell proliferation
Prostaglandin secretion
Prostaglandin transport
Response to drug
Response to organic cyclic compound
Response to organonitrogen compound
Transmembrane transport
Transport across blood-brain barrier
Urate transport

Basolateral cell membrane; Apical cell membrane. Its localization to the basolateral or apical membranes is tissue-dependent.

N-glycosylated; leading to substrate-selective effects on its transport activity.