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Rat Anti-ABCC4 Recombinant Antibody (V2-179025) (CBMAB-A0261-YC)


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Summary

Host Animal
Rat
Specificity
Human
Clone
V2-179025
Antibody Isotype
IgG2a
Application
ICC, IF, IHC-Fr, WB

Basic Information

Immunogen
Raised against amino acids 372-431 of MRP4 of human origin.
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:10-1:200
IHC1:10-1:200
FC10-20 µl/10^6 cells
IF(ICC)1:10-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ATP-binding cassette, sub-family C (CFTR/MRP), member 4
Introduction
ABCC4 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN
Entrez Gene ID
10257
UniProt ID
O15439
Alternative Names
ATP Binding Cassette Subfamily C Member 4; Canalicular Multispecific Organic Anion Transporter (ABC Superfamily); BA464I2.1 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4); Multi-Specific Organic Anion Transporter B; Multidrug Resistance-Associa
Function
ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules. Confers resistance to anticancer agents such as methotrexate.
Biological Process
Bile acid and bile salt transport
Bile acid signaling pathway
cAMP transport
Cilium assembly
Export across plasma membrane
Leukotriene transport
Platelet degranulation
Positive regulation of smooth muscle cell proliferation
Prostaglandin secretion
Prostaglandin transport
Response to drug
Response to organic cyclic compound
Response to organonitrogen compound
Transmembrane transport
Transport across blood-brain barrier
Urate transport
Cellular Location
Basolateral cell membrane; Apical cell membrane. Its localization to the basolateral or apical membranes is tissue-dependent.
PTM
N-glycosylated; leading to substrate-selective effects on its transport activity.
More Infomation

Zhao, J., & Jiang, G. (2020). Effect of Dual-Targeting MiR-4282 and ATP-Binding Cassette Sub-Family C Member 4 on Drug Resistance of Breast Cancer Cells and Its Molecular Mechanism. Journal of Biomaterials and Tissue Engineering, 10(4), 507-511.

Gao, M., Liu, L., Zhang, D., Yang, Y., & Chang, Z. (2020). Long non-coding RNA NEAT1 serves as sponge for miR-365a-3p to promote gastric cancer progression via regulating ABCC4. OncoTargets and therapy, 13, 3977.

Hardy, D., Bill, R. M., Jawhari, A., & Rothnie, A. J. (2019). Functional expression of multidrug resistance protein 4 MRP4/ABCC4. SLAS DISCOVERY: Advancing Life Sciences R&D, 24(10), 1000-1008.

Marcantoni, E., Allen, N., Cambria, M. R., Dann, R., Cammer, M., Lhakhang, T., ... & Berger, J. S. (2018). Platelet transcriptome profiling in HIV and ATP-binding cassette subfamily C member 4 (ABCC4) as a mediator of platelet activity. JACC: Basic to Translational Science, 3(1), 9-22.

Tanner, C., Boocock, J., Stahl, E. A., Dobbyn, A., Mandal, A. K., Cadzow, M., ... & Merriman, T. R. (2017). Population‐Specific Resequencing Associates the ATP‐Binding Cassette Subfamily C Member 4 Gene With Gout in New Zealand Māori and Pacific Men. Arthritis & Rheumatology, 69(7), 1461-1469.

Chen, Q., Meng, F., Wang, L., Mao, Y., Zhou, H., Hua, D., ... & Wang, W. (2017). A polymorphism in ABCC4 is related to efficacy of 5-FU/capecitabine-based chemotherapy in colorectal cancer patients. Scientific reports, 7(1), 1-7.

Flores, K., Manautou, J. E., & Renfro, J. L. (2017). Gender-specific expression of ATP-binding cassette (Abc) transporters and cytoprotective genes in mouse choroid plexus. Toxicology, 386, 84-92.

Tanha, H. M., Rahgozar, S., & Naeini, M. M. (2017). ABCC4 functional SNP in the 3′ splice acceptor site of exon 8 (G912T) is associated with unfavorable clinical outcome in children with acute lymphoblastic leukemia. Cancer chemotherapy and pharmacology, 80(1), 109-117.

Jang, H., Choi, Y., Yoo, I., Han, J., Kim, M., & Ka, H. (2017). Expression and regulation of prostaglandin transporters, ATP-binding cassette, subfamily C, member 1 and 9, and solute carrier organic anion transporter family, member 2A1 and 5A1 in the uterine endometrium during the estrous cycle and pregnancy in pigs. Asian-Australasian journal of animal sciences, 30(5), 643.

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For research use only. Not intended for any clinical use.

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