ABCC3

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

ATP BINDING CASSETTE SUBFAMILY C MEMBER 3

ATP-dependent transporter of the ATP-binding cassette (ABC) family that bind and hydrolyze ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate) (By similarity). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). Can confers resistance to various anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells.

Bile acid and bile salt transport
Canalicular bile acid transport
Drug transmembrane transport
Leukotriene transport
Transmembrane transport
Transport across blood-brain barrier
Xenobiotic transport

Basolateral cell membrane

Extracellular: 1-32 aa
Helical: 33-53 aa
Cytoplasmic: 54-73 aa
Helical: 74-94 aa
Extracellular: 95-99 aa
Helical: 100-120 aa
Cytoplasmic: 121-132 aa
Helical: 133-153 aa
Extracellular: 154-171 aa
Helical: 172-192 aa
Cytoplasmic: 193-302 aa
Helical: 303-323 aa
Extracellular: 324-349 aa
Helical: 350-370 aa
Cytoplasmic: 371-426 aa
Helical: 427-447 aa
Extracellular: 448-450 aa
Helical: 451-471 aa
Cytoplasmic: 472-533 aa
Helical: 534-554 aa
Extracellular: 555-576 aa
Helical: 577-597 aa
Cytoplasmic: 598-963 aa
Helical: 964-984 aa
Extracellular: 985-1021 aa
Helical: 1022-1042 aa
Cytoplasmic: 1043-1085 aa
Helical: 1086-1106 aa
Extracellular: 1107 aa
Helical: 1108-1128 aa
Cytoplasmic: 1129-1199 aa
Helical: 1200-1220 aa
Extracellular: 1221-1222 aa
Helical: 1223-1243 aa
Cytoplasmic: 1244-1527 aa