ABCC1

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms. [provided by RefSeq]

ATP-binding cassette, sub-family C (CFTR/MRP), member 1

Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export. Hydrolyzes ATP with low efficiency. Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation. Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells (By similarity).

Carboxylic acid transmembrane transport
Cell chemotaxis
Cellular response to amyloid-beta
Cobalamin metabolic process
Cobalamin transport
Export across plasma membrane
Glutathione transmembrane transport
Heme catabolic process
Leukotriene metabolic process
Leukotriene transport
Phospholipid translocation
Positive regulation of inflammatory response
Response to drug
Sphingolipid translocation
Transepithelial transport
Transmembrane transport
Transport across blood-brain barrier
Xenobiotic transport
Xenobiotic transport across blood-brain barrier

Cell membrane

A form of non-syndromic deafness characterized by adult onset of bilateral, postlingual, mild-to-severe sensorineural hearing loss. Sensorineural hearing loss results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.

Extracellular: 1-33 aa
Helical: 34-54 aa
Cytoplasmic: 55-74 aa
Helical: 75-95 aa
Extracellular: 96-100 aa
Helical: 101-121 aa
Cytoplasmic: 122-133 aa
Helical: 134-154 aa
Extracellular: 155-172 aa
Helical: 173-193 aa
Cytoplasmic: 194-316 aa
Helical: 317-337 aa
Extracellular: 338-363 aa
Helical: 364-384 aa
Cytoplasmic: 385-440 aa
Helical: 441-461 aa
Extracellular: 462-464 aa
Helical: 465-485 aa
Cytoplasmic: 486-547 aa
Helical: 548-568 aa
Extracellular: 569-590 aa
Helical: 591-611 aa
Cytoplasmic: 612-967 aa
Helical: 968-988 aa
Extracellular: 989-1025 aa
Helical: 1026-1046 aa
Cytoplasmic: 1047-1089 aa
Helical: 1090-1110 aa
Extracellular: 1111 aa
Helical: 1112-1132 aa
Cytoplasmic: 1133-1203 aa
Helical: 1204-1224 aa
Extracellular: 1225-1226 aa
Helical: 1227-1247 aa
Cytoplasmic: 1248-1531 aa