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Mouse Anti-ABCC1 Recombinant Antibody (V2-178995) (CBMAB-A0230-YC)


See all ABCC1 antibodies
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Published Data
Mouse Anti-ABCC1 Recombinant Antibody (QCRL2) (CBMAB-A0230-YC) in IHC
An immunohistochemistry assay was performed with tumor samples obtained after seven days of treatment against MRP1. ...View More
Torres, Á., Arriagada, V., Erices, J. I., Toro, M. D. L. Á., Rocha, J. D., Niechi, I., ... & Quezada, C. (2018). FK506 Attenuates the MRP1-mediated chemoresistant phenotype in glioblastoma stem-like cells. International Journal of Molecular Sciences, 19(9), 2697.
Mouse Anti-ABCC1 Recombinant Antibody (QCRL2) (CBMAB-A0230-YC) in WB
Western blot of MRP1 transporter in U87MG. ...View More
Torres, A., Vargas, Y., Uribe, D., Jaramillo, C., Gleisner, A., Salazar-Onfray, F., ... & Quezada, C. (2016). Adenosine A3 receptor elicits chemoresistance mediated by multiple resistance-associated protein-1 in human glioblastoma stem-like cells. Oncotarget, 7(41), 67373.
Mouse Anti-ABCC1 Recombinant Antibody (QCRL2) (CBMAB-A0230-YC) in FC
MRP1/ABCC1 activity: cells were incubated for 30 min with 5 μM CFDA in the presence of medium (C), 50 μM MK-571 (MK50) or the indicated concentrations of 3ATA, and the intracellular fluorescence was evaluated using flow cytometry. ...View More
da Graça Rocha, G., Oliveira, R. R., Kaplan, M. A. C., & Gattass, C. R. (2014). 3β-Acetyl tormentic acid reverts MRP1/ABCC1 mediated cancer resistance through modulation of intracellular levels of GSH and inhibition of GST activity. European Journal of Pharmacology, 741, 140-149.

Summary

Host Animal
Mouse
Specificity
Human, Monkey, Mouse, Rat
Clone
V2-178995
Antibody Isotype
IgG2b
Application
FC, FuncS, IF, IP

Basic Information

Immunogen
Raised against non-denatured membranes prepared from H69AR small cell lung cancer cell line of human origin
Specificity
Human, Monkey, Mouse, Rat
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
ELISA1:30-1:3,000
IF(ICC)1:50-1:500
IP1-2 µl per 100-500 µg of total protein (1 ml of cell lysate)

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Introduction
ABCC1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN2
Entrez Gene ID
Human4363
Mouse17250
Rat24565
Monkey717857
UniProt ID
HumanP33527
MouseO35379
RatQ8CG09
MonkeyQ864R9
Alternative Names
ATP Binding Cassette Subfamily C Member 1; ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1; Leukotriene C(4) Transporter; LTC4 Transporter; MRP1; MRP; ATP-Binding Cassette Transporter Variant ABCC1delta-Ex13&14; ATP-Binding Cassette Transporter Va
Function
Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export. Hydrolyzes ATP with low efficiency. Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation. Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells (By similarity).
Biological Process
Carboxylic acid transmembrane transport
Cell chemotaxis
Cellular response to amyloid-beta
Cobalamin metabolic process
Cobalamin transport
Export across plasma membrane
Glutathione transmembrane transport
Heme catabolic process
Leukotriene metabolic process
Leukotriene transport
Phospholipid translocation
Positive regulation of inflammatory response
Response to drug
Sphingolipid translocation
Transepithelial transport
Transmembrane transport
Transport across blood-brain barrier
Xenobiotic transport
Xenobiotic transport across blood-brain barrier
Cellular Location
Cell membrane
Involvement in disease
A form of non-syndromic deafness characterized by adult onset of bilateral, postlingual, mild-to-severe sensorineural hearing loss. Sensorineural hearing loss results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Topology
Extracellular: 1-33 aa
Helical: 34-54 aa
Cytoplasmic: 55-74 aa
Helical: 75-95 aa
Extracellular: 96-100 aa
Helical: 101-121 aa
Cytoplasmic: 122-133 aa
Helical: 134-154 aa
Extracellular: 155-172 aa
Helical: 173-193 aa
Cytoplasmic: 194-316 aa
Helical: 317-337 aa
Extracellular: 338-363 aa
Helical: 364-384 aa
Cytoplasmic: 385-440 aa
Helical: 441-461 aa
Extracellular: 462-464 aa
Helical: 465-485 aa
Cytoplasmic: 486-547 aa
Helical: 548-568 aa
Extracellular: 569-590 aa
Helical: 591-611 aa
Cytoplasmic: 612-967 aa
Helical: 968-988 aa
Extracellular: 989-1025 aa
Helical: 1026-1046 aa
Cytoplasmic: 1047-1089 aa
Helical: 1090-1110 aa
Extracellular: 1111 aa
Helical: 1112-1132 aa
Cytoplasmic: 1133-1203 aa
Helical: 1204-1224 aa
Extracellular: 1225-1226 aa
Helical: 1227-1247 aa
Cytoplasmic: 1248-1531 aa
More Infomation

Jepsen, W. (2021). Adenosine Triphosphate Binding Cassette Subfamily C Member 1 (ABCC1) Modulates Amyloid Precursor Protein (App) Processing: a Potential Therapeutic Target for the Treatment of Alzheimer’s Disease (Doctoral dissertation, Arizona State University).

Chen, X. Y., Yang, Y., Wang, J. Q., Wu, Z. X., Li, J., & Chen, Z. S. (2021). Overexpression of ABCC1 confers drug resistance to betulin. Frontiers in oncology, 11.

Gallman, A. E., Wolfreys, F. D., Nguyen, D. N., Sandy, M., Xu, Y., An, J., ... & Cyster, J. G. (2021). Abcc1 and Ggt5 support lymphocyte guidance through export and catabolism of S-geranylgeranyl-L-glutathione. Science Immunology, 6(60).

Zhang, L., Huang, P., Huang, C., Jiang, L., Lu, Z., & Wang, P. (2021). Varied clinical significance of ATP-binding cassette C sub-family members for lung adenocarcinoma. Medicine, 100(16).

Huang, W., Huang, F., & Feng, C. (2020). CircFoxo3 promotes adriamycin resistance through regulation of miR-199a-5p/ATP binding cassette subfamily C member 1 Axis in hepatocellular carcinoma. OncoTargets and therapy, 13, 5113.

Low, F. (2019). ATP-binding cassette subfamily C (ABCC) transporter 1 (ABCC1) and 4 (ABCC4) independent of their drug efflux ability affects breast cancer biology (Doctoral dissertation, Aston University).

Jang, H., Choi, Y., Yoo, I., Han, J., Kim, M., & Ka, H. (2017). Expression and regulation of prostaglandin transporters, ATP-binding cassette, subfamily C, member 1 and 9, and solute carrier organic anion transporter family, member 2A1 and 5A1 in the uterine endometrium during the estrous cycle and pregnancy in pigs. Asian-Australasian journal of animal sciences, 30(5), 643.

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For research use only. Not intended for any clinical use.

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