EGF

This gene encodes a member of the epidermal growth factor superfamily. The encoded preproprotein is proteolytically processed to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding with high affinity to the cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]

Epidermal Growth Factor

EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro (PubMed:10964941).

Angiogenesis Source: HGNC-UCL
Branching morphogenesis of an epithelial tube Source: Ensembl
Epidermal growth factor receptor signaling pathway Source: BHF-UCL
Epidermal growth factor receptor signaling pathway via MAPK cascade Source: UniProtKB
ERK1 and ERK2 cascade Source: UniProtKB
Mammary gland alveolus development Source: Ensembl
Negative regulation of cholesterol efflux Source: Ensembl
Negative regulation of secretion Source: BHF-UCL
Peptidyl-tyrosine phosphorylation Source: Ensembl
Positive regulation of canonical Wnt signaling pathway Source: BHF-UCL
Positive regulation of cell migration Source: UniProtKB
Positive regulation of cell population proliferation Source: HGNC-UCL
Positive regulation of cerebellar granule cell precursor proliferation Source: Ensembl
Positive regulation of DNA binding Source: UniProtKB
Positive regulation of DNA replication Source: UniProtKB
Positive regulation of endothelial cell migration Source: BHF-UCL
Positive regulation of endothelial cell proliferation Source: BHF-UCL
Positive regulation of epidermal growth factor-activated receptor activity Source: UniProtKB
Positive regulation of epithelial tube formation Source: BHF-UCL
Positive regulation of gene expression Source: UniProtKB
Positive regulation of hyaluronan biosynthetic process Source: UniProtKB
Positive regulation of MAPK cascade Source: BHF-UCL
Positive regulation of MAP kinase activity Source: HGNC-UCL
Positive regulation of mitotic nuclear division Source: HGNC-UCL
Positive regulation of peptidyl-threonine phosphorylation Source: UniProtKB
Positive regulation of phosphatidylinositol 3-kinase signaling Source: BHF-UCL
Positive regulation of phosphorylation Source: HGNC-UCL
Positive regulation of protein kinase B signaling Source: BHF-UCL
Positive regulation of protein localization to early endosome Source: UniProtKB
Positive regulation of receptor internalization Source: ParkinsonsUK-UCL
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of ubiquitin-dependent protein catabolic process Source: Ensembl
Regulation of calcium ion import Source: BHF-UCL
Regulation of protein localization to cell surface Source: BHF-UCL
Regulation of receptor signaling pathway via JAK-STAT Source: UniProtKB

Membrane

Hypomagnesemia 4 (HOMG4):
A disorder characterized by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion. Clinical features include seizures, mild-to moderate psychomotor retardation, and brisk tendon reflexes.

Extracellular: 23-1032
Helical: 1033-1053
Cytoplasmic: 1054-1207

O-glycosylated with core 1-like and core 2-like glycans. It is uncertain if Ser-954 or Thr-955 is O-glycosylated. The modification here shows glycan heterogeneity: HexHexNAc (major) and Hex2HexNAc2 (minor).