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Rabbit Anti-AKR1B1 Recombinant Antibody (V2-180461) (CBMAB-A1969-YC)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
V2-180461
Antibody Isotype
IgG
Application
WB, ELISA, IP, ICC/IF

Basic Information

Immunogen
Recombinant Human AKR1B1 protein
Host Species
Rabbit
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IP0.2-1 μl/mg of lysate
IF(ICC)1:20-1:100
WB1:500-1:2,000
ELISA1:5,000-1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Aldo-Keto Reductase Family 1 Member B
Introduction
AKR1B1 is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the de
Entrez Gene ID
231
UniProt ID
P15121
Alternative Names
Aldo-Keto Reductase Family 1 Member B; Aldo-Keto Reductase Family 1 Member B1; Aldose Reductase; EC 1.1.1.21; ALDR1; AR; Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase); Lii5-2 CTCL Tumor Antigen;
Function
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia (PubMed:1936586). Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal (PubMed:12732097, PubMed:19010934, PubMed:8343525). Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides (PubMed:17381426). Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (PubMed:21329684).
Biological Process
C21-steroid hormone biosynthetic process Source: Reactome
Carbohydrate metabolic process Source: ProtInc
Cellular hyperosmotic salinity response Source: UniProtKB
Cellular response to methylglyoxal Source: Ensembl
Cellular response to peptide Source: Ensembl
Daunorubicin metabolic process Source: UniProtKB
Doxorubicin metabolic process Source: UniProtKB
Epithelial cell maturation Source: Ensembl
Fructose biosynthetic process Source: Reactome
Inner medullary collecting duct development Source: Ensembl
Maternal process involved in female pregnancy Source: Ensembl
Metanephric collecting duct development Source: Ensembl
Naphthalene metabolic process Source: Ensembl
Negative regulation of apoptotic process Source: Ensembl
Norepinephrine metabolic process Source: Ensembl
Positive regulation of receptor signaling pathway via JAK-STAT Source: Ensembl
Positive regulation of smooth muscle cell proliferation Source: Ensembl
Regulation of urine volume Source: Ensembl
Renal water homeostasis Source: Ensembl
Response to thyroid hormone Source: Ensembl
Response to water deprivation Source: Ensembl
Retinoid metabolic process Source: UniProtKB
Sorbitol biosynthetic process Source: Ensembl
Stress-activated protein kinase signaling cascade Source: Ensembl
Tissue homeostasis Source: Ensembl
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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