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PHKG2 Matched Antibody Pair (875) (APMAB-875LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-PHKG2 monoclonal, IgG2a antibody, 100 ug
Detection Antibody
Anti-PHKG2 Biotinylated mouse monoclonal, IgG2a antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, and the hepatic isoform is encoded by this gene. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9C, also known as autosomal liver glycogenosis. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]
Alternative Names
Phosphorylase Kinase Catalytic Subunit Gamma 2; Phosphorylase Kinase, Gamma 2 (Testis); Phosphorylase Kinase Subunit Gamma-2; PHK-Gamma-LT; EC 2.7.11.19; PHK-Gamma-T; PSK-C3; Phosphorylase B Kinase Gamma Catalytic Chain, Liver/Testis Isoform;
Entrez Gene ID
5261
UniProt ID
P15735
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For research use only. Not intended for any clinical use.

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