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NR3C1 Matched Antibody Pair (818) (APMAB-818LY)


See all NR3C1 antibodies
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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-NR3C1 polyclonal antibody, 100 ug
Detection Antibody
Anti-NR3C1 Mouse monoclonal, IgG2a antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
Alternative Names
Nuclear Receptor Subfamily 3 Group C Member 1; Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor); Glucocorticoid Receptor; GRL; GR; Nuclear Receptor Subfamily 3, Group C, Member 1;
Entrez Gene ID
2908
UniProt ID
P04150
More Infomation

Yan, C., He, X., Qi, R., Cao, L., Zheng, S., Huang, C., ... & Liu, X. (2023). Prediction and prognostic potential of NR3C1 gene expression level in DLBCL patients. Hematology, 28(1), 2251199.

Chalfun, G., Reis, M. M., de Oliveira, M. B. G., de Araújo Brasil, A., dos Santos Salú, M., da Cunha, A. J. L. A., ... & de Magalhaes-Barbosa, M. C. (2022). Perinatal stress and methylation of the NR3C1 gene in newborns: systematic review. Epigenetics, 17(9), 1003-1019.

Miao, H., Liu, Y., Lu, L., Gong, F., Wang, L., Duan, L., ... & Zhu, H. (2021). Effect of 3 NR3C1 mutations in the pathogenesis of pituitary ACTH adenoma. Endocrinology, 162(11), bqab167.

Berretta, E., Guida, E., Forni, D., & Provenzi, L. (2021). Glucocorticoid receptor gene (NR3C1) methylation during the first thousand days: Environmental exposures and developmental outcomes. Neuroscience & Biobehavioral Reviews, 125, 493-502.

de Assis Pinheiro, J., Freitas, F. V., Borçoi, A. R., Mendes, S. O., Conti, C. L., Arpini, J. K., ... & Alvares-da-Silva, A. M. (2021). Alcohol consumption, depression, overweight and cortisol levels as determining factors for NR3C1 gene methylation. Scientific Reports, 11(1), 6768.

Ramírez, C. G., Queijeiro, A. V., Morales, S. J., López, D. B., Miranda, A. H., Chow, A. R., ... & Estrada, M. G. (2020). The NR3C1 gene expression is a potential surrogate biomarker for risk and diagnosis of posttraumatic stress disorder. Psychiatry Research, 284, 112797.

Bakusic, J., Vrieze, E., Ghosh, M., Bekaert, B., Claes, S., & Godderis, L. (2020). Increased methylation of NR3C1 and SLC6A4 is associated with blunted cortisol reactivity to stress in major depression. Neurobiology of Stress, 13, 100272.

Borçoi, A. R., Mendes, S. O., Dos Santos, J. G., de Oliveira, M. M., Moreno, I. A. A., Freitas, F. V., ... & Álvares-da-Silva, A. M. (2020). Risk factors for depression in adults: NR3C1 DNA methylation and lifestyle association. Journal of psychiatric research, 121, 24-30.

Holmes Jr, L., Shutman, E., Chinaka, C., Deepika, K., Pelaez, L., & Dabney, K. W. (2019). Aberrant epigenomic modulation of glucocorticoid receptor gene (NR3C1) in early life stress and major depressive disorder correlation: systematic review and quantitative evidence synthesis. International journal of environmental research and public health, 16(21), 4280.

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For research use only. Not intended for any clinical use.

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