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NFKB1 Matched Antibody Pair (795) (APMAB-795LY)


See all NFKB1 antibodies
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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-NFKB1 polyclonal antibody, 100 ug
Detection Antibody
Anti-NFKB1 Mouse polyclonal antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. [provided by RefSeq, Feb 2016]
Alternative Names
Nuclear Factor Kappa B Subunit 1; Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 1; DNA-Binding Factor KBF1; EBP-1; Nuclear Factor Kappa-B DNA Binding Subunit; Nuclear Factor NF-Kappa-B P105 Subunit; Nuclear Factor NF-Kappa-B P50 Subunit; NF-Kappabeta; NF-Kappa-B; NF-KappaB;
Entrez Gene ID
4790
UniProt ID
P19838
More Infomation

Fliegauf, M., Krüger, R., Steiner, S., Hanitsch, L. G., Büchel, S., Wahn, V., ... & Grimbacher, B. (2021). A pathogenic missense variant in NFKB1 causes common variable immunodeficiency due to detrimental protein damage. Frontiers in Immunology, 12, 621503.

Li, J., Lei, W. T., Zhang, P., Rapaport, F., Seeleuthner, Y., Lyu, B., ... & Boisson, B. (2021). Biochemically deleterious human NFKB1 variants underlie an autosomal dominant form of common variable immunodeficiency. Journal of Experimental Medicine, 218(11), e20210566.

Somma, D., Kok, F. O., Kerrigan, D., Wells, C. A., & Carmody, R. J. (2021). Defining the role of nuclear factor (NF)-κB p105 subunit in human macrophage by transcriptomic analysis of NFKB1 knockout THP1 cells. Frontiers in Immunology, 12, 669906.

Mandola, A. B., Sharfe, N., Nagdi, Z., Dadi, H., Vong, L., Merico, D., ... & Roifman, C. M. (2021). Combined immunodeficiency caused by a novel homozygous NFKB1 mutation. Journal of Allergy and Clinical Immunology, 147(2), 727-733.

Lorenzini, T., Fliegauf, M., Klammer, N., Frede, N., Proietti, M., Bulashevska, A., ... & Karim, Y. (2020). Characterization of the clinical and immunologic phenotype and management of 157 individuals with 56 distinct heterozygous NFKB1 mutations. Journal of Allergy and Clinical Immunology, 146(4), 901-911.

Low, J. T., Christie, M., Ernst, M., Dumoutier, L., Preaudet, A., Ni, Y., ... & O’Reilly, L. A. (2020). Loss of NFKB1 results in expression of tumor necrosis factor and activation of signal transducer and activator of transcription 1 to promote gastric tumorigenesis in mice. Gastroenterology, 159(4), 1444-1458.

Best, K. T., Lee, F. K., Knapp, E., Awad, H. A., & Loiselle, A. E. (2019). Deletion of NFKB1 enhances canonical NF-κB signaling and increases macrophage and myofibroblast content during tendon healing. Scientific reports, 9(1), 10926.

Coto, E., Reguero, J. R., Avanzas, P., Pascual, I., Martín, M., Hevia, S., ... & Gómez, J. (2019). Gene variants in the NF-KB pathway (NFKB1, NFKBIA, NFKBIZ) and risk for early-onset coronary artery disease. Immunology letters, 208, 39-43.

Li, L., & Zhang, Z. T. (2019). Genetic association between NFKBIA and NFKB1 gene polymorphisms and the susceptibility to head and neck cancer: a meta-analysis. Disease markers, 2019.

Schröder, C., Sogkas, G., Fliegauf, M., Dörk, T., Liu, D., Hanitsch, L. G., ... & Atschekzei, F. (2019). Late-onset antibody deficiency due to monoallelic alterations in NFKB1. Frontiers in Immunology, 10, 2618.

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For research use only. Not intended for any clinical use.

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