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NEDD9 Matched Antibody Pair (784) (APMAB-784LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-NEDD9 polyclonal antibody, 100 ug
Detection Antibody
Anti-NEDD9 Mouse monoclonal, IgG1 antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported to have a role in cancer metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Alternative Names
Neural Precursor Cell Expressed, Developmentally Down-Regulated 9; Cas Scaffolding Protein Family Member 2; Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 9; Renal Carcinoma Antigen NY-REN-12; CAS-L; CASS2; HEF1; CASL; Crk-Associated Substrate Related Protein Cas-L; CRK-Associated Substrate-Related Protein;
Entrez Gene ID
4739
UniProt ID
Q14511
More Infomation

Hu, Z., Wei, F., Su, Y., Wang, Y., Shen, Y., Fang, Y., ... & Chen, Y. (2023). Histone deacetylase inhibitors promote breast cancer metastasis by elevating NEDD9 expression. Signal Transduction and Targeted Therapy, 8(1), 11.

Deneka, A. Y., Nikonova, A. S., Lee, H. O., Kruger, W. D., & Golemis, E. A. (2022). NEDD9 sustains hexokinase expression to promote glycolysis. Oncogenesis, 11(1), 15.

Deneka, A. Y., Kopp, M. C., Nikonova, A. S., Gaponova, A. V., Kiseleva, A. A., Hensley, H. H., ... & Golemis, E. A. (2021). Nedd9 Restrains Autophagy to Limit Growth of Early Stage Non–Small Cell Lung Cancer. Cancer research, 81(13), 3717-3726.

Alba, G. A., Samokhin, A. O., Wang, R. S., Zhang, Y. Y., Wertheim, B. M., Arons, E., ... & Maron, B. A. (2021). NEDD9 is a novel and modifiable mediator of platelet–endothelial adhesion in the pulmonary circulation. American journal of respiratory and critical care medicine, 203(12), 1533-1545.

Hua, S., Feng, T., Yin, L., Wang, Q., & Shao, X. (2021). NEDD9 overexpression: Prognostic and guidance value in acute myeloid leukaemia. Journal of cellular and molecular medicine, 25(19), 9331-9339.

Samokhin, A. O., Hsu, S., Paul, B. Y., Waxman, A. B., Alba, G. A., Wertheim, B. M., ... & Maron, B. A. (2020). Circulating NEDD9 is increased in pulmonary arterial hypertension: a multicenter, retrospective analysis. The Journal of Heart and Lung Transplantation, 39(4), 289-299.

Meng, H., Wu, J., Huang, Q., Yang, X., Yang, K., Qiu, Y., ... & Qi, H. (2019). NEDD9 promotes invasion and migration of colorectal cancer cell line HCT116 via JNK/EMT. Oncology Letters, 18(4), 4022-4029.

Gu, Y., Lu, J., Chen, C., & Zheng, F. (2019). NEDD9 overexpression predicts poor prognosis in solid cancers: a meta-analysis. OncoTargets and therapy, 12, 4213.

Zhao, S., Min, P., Liu, L., Zhang, L., Zhang, Y., Wang, Y., ... & Gu, L. (2019). NEDD9 facilitates hypoxia-induced gastric cancer cell migration via MICAL1 related Rac1 activation. Frontiers in pharmacology, 10, 291.

Jurčić, P., Radulović, P., Balja, M. P., Milošević, M., & Krušlin, B. (2019). E‑cadherin and NEDD9 expression in primary colorectal cancer, metastatic lymph nodes and liver metastases. Oncology Letters, 17(3), 2881-2889.

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For research use only. Not intended for any clinical use.

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