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MYOC Matched Antibody Pair (772) (APMAB-772LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-MYOC polyclonal antibody, 100 ug
Detection Antibody
Anti-MYOC Mouse monoclonal, IgG1 antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. MYOC is expressed in many occular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshwork glucocorticoid-inducible response protein (TIGR). The trabecular meshwork is a specialized eye tissue essential in regulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma. [provided by RefSeq, Jul 2008]
Alternative Names
Myocilin; Trabecular Meshwork Inducible Glucocorticoid Response Protein; Juvenile-Onset Open-Angle Glaucoma 1; Myocilin 55 KDa Subunit; GLC1A; TIGR; Myocilin Trabecular Meshwork Inducible Glucocorticoid Response Protein;
Entrez Gene ID
4653
UniProt ID
Q99972
More Infomation

Saccuzzo, E. G., Youngblood, H. A., & Lieberman, R. L. (2023). Myocilin misfolding and glaucoma: A 20-year update. Progress in Retinal and Eye Research, 101188.

Zhou, B., Lin, X., Li, Z., Yao, Y., Yang, J., & Zhu, Y. (2022). Structure‒function‒pathogenicity analysis of C-terminal myocilin missense variants based on experiments and 3D models. Frontiers in Genetics, 13, 1019208.

Nakahara, E., & Hulleman, J. D. (2022). A simple secretion assay for assessing new and existing myocilin variants. Current eye research, 47(6), 918-922.

Sharma, R., & Grover, A. (2021). Myocilin-associated glaucoma: a historical perspective and recent research progress. Molecular Vision, 27, 480.

Atienzar-Aroca, R., Aroca-Aguilar, J. D., Alexandre-Moreno, S., Ferre-Fernández, J. J., Bonet-Fernández, J. M., Cabañero-Varela, M. J., & Escribano, J. (2021). Knockout of myoc Provides Evidence for the Role of Myocilin in Zebrafish Sex Determination Associated with Wnt Signalling Downregulation. Biology, 10(2), 98.

Judge, S. M., Deyhle, M. R., Neyroud, D., Nosacka, R. L., D'Lugos, A. C., Cameron, M. E., ... & Judge, A. R. (2020). MEF2c-dependent downregulation of myocilin mediates cancer-induced muscle wasting and associates with cachexia in patients with cancer. Cancer research, 80(9), 1861-1874.

O’Gorman, L., Cree, A. J., Ward, D., Griffiths, H. L., Sood, R., Denniston, A. K., ... & Gibson, J. (2019). Comprehensive sequencing of the myocilin gene in a selected cohort of severe primary open-angle glaucoma patients. Scientific reports, 9(1), 3100.

Alward, W. L., Van Der Heide, C., Khanna, C. L., Roos, B. R., Sivaprasad, S., Kam, J., ... & NEIGHBORHOOD Consortium. (2019). Myocilin mutations in patients with normal-tension glaucoma. JAMA ophthalmology, 137(5), 559-563.

Wang, H., Li, M., Zhang, Z., Xue, H., Chen, X., & Ji, Y. (2019). Physiological function of myocilin and its role in the pathogenesis of glaucoma in the trabecular meshwork. International journal of molecular medicine, 43(2), 671-681.

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For research use only. Not intended for any clinical use.

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