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Mouse Anti-AKR1B10 Recombinant Antibody (V2-180470) (CBMAB-A1978-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-180470
Antibody Isotype
IgG1, κ
Application
ELISA, IF, WB

Basic Information

Immunogen
AKR1B10 (NP_064695, 76-143 aa) partial recombinant protein with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IF(ICC)10 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 76-143

Target

Full Name
Aldo-Keto Reductase Family 1 Member B10
Introduction
AKR1B10 is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal
Entrez Gene ID
57016
UniProt ID
O60218
Alternative Names
Aldo-Keto Reductase Family 1 Member B10; Aldose Reductase-Related Protein; Small Intestine Reductase; Aldo-Keto Reductase Family 1, Member B11 (Aldose Reductase-Like); Aldo-Keto Reductase Family 1, Member B10 (Aldose Reductase); Aldose Reductase-Like Pept
Function
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:9565553, PubMed:18087047, PubMed:12732097, PubMed:19013440, PubMed:19563777). Displays strong enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal (PubMed:12732097, PubMed:18087047). Plays a critical role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (PubMed:19013440, PubMed:19563777). Displays no reductase activity towards glucose (PubMed:12732097).
Biological Process
Cellular detoxification of aldehyde Source: UniProtKB
Daunorubicin metabolic process Source: UniProtKB
Doxorubicin metabolic process Source: UniProtKB
Farnesol catabolic process Source: UniProtKB
Retinoid metabolic process Source: UniProtKB
Cellular Location
Lysosome; Secreted. Secreted through a lysosome-mediated non-classical pathway.
More Infomation

Liu, R., Zheng, S., yan Yang, C., Yu, Y., Peng, S., Ge, Q., ... & Shao, Y. (2021). Prognostic value of aldo-keto reductase family 1 member B10 (AKR1B10) in digestive system cancers: A meta-analysis. Medicine, 100(14).

Chen, D., Shen, Z., Cheng, X., Wang, Q., Zhou, J., Ren, F., ... & Huang, R. (2021). Homeobox A5 activates p53 pathway to inhibit proliferation and promote apoptosis of adrenocortical carcinoma cells by inducing Aldo-Keto reductase family 1 member B10 expression. Bioengineered, 12(1), 1964-1975.

Kanno, M., Kawaguchi, K., Honda, M., Horii, R., Takatori, H., Shimakami, T., ... & Kaneko, S. (2019). Serum aldo–keto reductase family 1 member B10 predicts advanced liver fibrosis and fatal complications of nonalcoholic steatohepatitis. Journal of gastroenterology, 54(6), 549-557.

Ye, X., Li, C., Zu, X., Lin, M., Liu, Q., Liu, J., ... & Cao, D. (2019). A large‐scale multicenter study validates aldo‐keto reductase family 1 member B10 as a prevalent serum marker for detection of hepatocellular carcinoma. Hepatology, 69(6), 2489-2501.

Shi, J., Chen, L., Chen, Y., Lu, Y., Chen, X., & Yang, Z. (2019). Aldo-Keto Reductase Family 1 Member B10 (AKR1B10) overexpression in tumors predicts worse overall survival in hepatocellular carcinoma. Journal of Cancer, 10(20), 4892.

Liu, W., Song, J., Du, X., Zhou, Y., Li, Y., Li, R., ... & Wang, Q. (2019). AKR1B10 (Aldo-keto reductase family 1 B10) promotes brain metastasis of lung cancer cells in a multi-organ microfluidic chip model. Acta biomaterialia, 91, 195-208.

Han, C., Gao, L., Zhao, L., Sheng, Q., Zhang, C., An, Z., ... & Dou, X. (2018). Immunohistochemistry detects increased expression of aldo-keto reductase family 1 member b10 (AKR1B10) in early-stage hepatocellular carcinoma. Medical science monitor: international medical journal of experimental and clinical research, 24, 7414.

Han, C., Gao, L., Bai, H., & Dou, X. (2018). Identification of a role for serum aldo‑keto reductase family 1 member B10 in early detection of hepatocellular carcinoma. Oncology Letters, 16(6), 7123-7130.

Zhou, Z., Zhao, Y., Gu, L., Niu, X., & Lu, S. (2018). Inhibiting proliferation and migration of lung cancer using small interfering RNA targeting on Aldo-keto reductase family 1 member B10. Molecular medicine reports, 17(2), 2153-2160.

Mori, M., Genda, T., Ichida, T., Murata, A., Kamei, M., Tsuzura, H., ... & Watanabe, S. (2017). Aldo‐keto reductase family 1 member B10 is associated with hepatitis B virus‐related hepatocellular carcinoma risk. Hepatology Research, 47(3), E85-E93.

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For research use only. Not intended for any clinical use.

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