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Mouse Anti-AK2 Recombinant Antibody (V2-180386) (CBMAB-A1858-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-180386
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
AK2 (AAH09405, 1 a.a. ~ 239 a.a) full-length recombinant protein with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Adenylate Kinase 2
Introduction
Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified
Entrez Gene ID
204
UniProt ID
P54819
Alternative Names
Adenylate Kinase 2; Adenylate Monophosphate Kinase; ATP-AMP Transphosphorylase 2; ATP:AMP Phosphotransferase; EC 2.7.4.3; ADK2;
Function
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
Biological Process
ADP biosynthetic process Source: UniProtKB-UniRule
AMP metabolic process Source: UniProtKB-UniRule
ATP metabolic process Source: UniProtKB-UniRule
Nucleobase-containing small molecule interconversion Source: Reactome
Cellular Location
Mitochondrion intermembrane space
Involvement in disease
Reticular dysgenesis (RDYS): A fatal form of severe combined immunodeficiency, characterized by absence of granulocytes, almost complete deficiency of lymphocytes in peripheral blood, hypoplasia of the thymus and secondary lymphoid organs, and lack of innate and adaptive humoral and cellular immunity, leading to fatal septicemia within days after birth. In bone marrow of individuals with reticular dysgenesis, myeloid differentiation is blocked at the promyelocytic stage, whereas erythro- and megakaryocytic maturation is generally normal. Inheritance is autosomal recessive.
More Infomation

Zhang, S., Yamada, S., Park, S., Klepinin, A., Kaambre, T., Terzic, A., & Dzeja, P. (2021). Adenylate kinase AK2 isoform integral in embryo and adult heart homeostasis. Biochemical and Biophysical Research Communications, 546, 59-64.

Maslah, N., Latiri, M., Asnafi, V., Féroul, M., Bedjaoui, N., Steimlé, T., ... & Andrieu, G. P. (2021). Adenylate kinase 2 expression and addiction in T-ALL. Blood advances, 5(3), 700-710.

Sobh, A., Kaestner, C., Li, J., Riva, A., Bennett, R. L., & Licht, J. D. (2020). Adenylate Kinase 2 Is a Selective Dependency in NSD2-High Multiple Myeloma. Blood, 136, 31.

Wang, W., Devilbiss, A., Mathews, T., Arreola, M., Martin, M., Zhao, Z., ... & Weinacht, K. G. (2020). Reticular Dysgenesis-Associated Adenylate Kinase 2 Deficiency Impairs Hematopoietic Stem and Progenitor Cell Function through Reductive Stress. Blood, 136, 33.

Liu, H., Pu, Y., Amina, Q., Wang, Q., Zhang, M., Song, J., ... & Mardan, M. (2019). Prognostic and therapeutic potential of Adenylate kinase 2 in lung adenocarcinoma. Scientific reports, 9(1), 1-10.

Ghaloul-Gonzalez, L., Mohsen, A. W., Karunanidhi, A., Seminotti, B., Chong, H., Madan-Khetarpal, S., ... & Vockley, J. (2019). Reticular dysgenesis and mitochondriopathy induced by adenylate kinase 2 deficiency with atypical presentation. Scientific reports, 9(1), 1-8.

Wang, W., Awani, A., Devilbiss, A., Mathews, T., Thomas, D., Dever, D. P., ... & Weinacht, K. G. (2019). Adenylate Kinase 2 Links Energy Metabolism and Cell Fate in Hematopoietic Stem and Progenitor Cells.

Waldmann, R. (2018). Investigations on the molecular biology of human adenylate kinase 2 deficiency (reticular dysgenesis) and the establishment and characterisation of an adenylate kinase 2-deficient mouse model (Doctoral dissertation, Universität Ulm).

Qiasita, D., Indarto, D., & Suselo, Y. H. (2018, July). Screening of Indonesian Phytochemicals as Adenylate Kinase 2 Inhibitor for Cancer Therapy. In 2018 2nd International Conference on Biomedical Engineering (IBIOMED) (pp. 25-28). IEEE.

Ji, E. H., Cui, L., Yuan, X., Cheng, S., Messadi, D., Yan, X., & Hu, S. (2017). Metabolomic analysis of human oral cancer cells with adenylate kinase 2 or phosphorylate glycerol kinase 1 inhibition. Journal of Cancer, 8(2), 298.

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For research use only. Not intended for any clinical use.

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