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MICA Matched Antibody Pair (735) (APMAB-735LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-MICA polyclonal antibody, 100 ug
Detection Antibody
Anti-MICA Mouse polyclonal antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Alternative Names
MHC Class I Polypeptide-Related Sequence A; PERB11.1; MIC-A; Truncated MHC Class I Polypeptide-Related Sequence A; MHC Class I Chain-Related Protein A; Stress Inducible Class I Homolog; MHC Class I Related Sequence A; MHC Class I Related Chain A; HLA Class I Antigen;
Entrez Gene ID
4276
UniProt ID
Q29983
More Infomation

Ren, X., Mao, A., Tan, S., Liu, J., & Wei, X. (2022). Analysis of the association between MICA gene polymorphisms and schizophrenia. Journal of Clinical Laboratory Analysis, 36(11), e24721.

Espinoza, I., Agarwal, S., Sakiyama, M., Shenoy, V., Orr, W. S., Al Diffalha, S., ... & Gomez, C. R. (2021). Expression of MHC class I polypeptide-related sequence A (MICA) in colorectal cancer.

Closa, L., Vidal, F., Herrero, M. J., & Caro, J. L. (2021). High‐throughput genotyping of HLA‐G, HLA‐F, MICA, and MICB and analysis of frequency distributions in healthy blood donors from Catalonia. HLA, 97(5), 420-427.

Otoyama, Y., Arai, J., Goto, K., Nozawa, H., Nakagawa, R., Muroyama, R., ... & Yoshida, H. (2021). Retinoids decrease soluble MICA concentration by inhibiting the enzymatic activity of ADAM9 and ADAM10. Anticancer Research, 41(5), 2307-2320.

Gong, X., Chen, P., Ma, P., Gao, J., Yang, J., Guo, H., ... & He, Y. (2020). MICA polymorphisms associated with antithyroid drug‐induced agranulocytosis in the Chinese Han population. Immunity, Inflammation and Disease, 8(4), 695-703.

Plasil, M., Wijkmark, S., Elbers, J. P., Oppelt, J., Burger, P. A., & Horin, P. (2019). The major histocompatibility complex of Old World camelids: class I and class I‐related genes. Hla, 93(4), 203-215.

Sakiyama, M. J., Espinoza, I., Reddy, A., de Carlo, F., Kumar, A., Levenson, A. S., ... & Gomez, C. R. (2019). Race-associated expression of MHC class I polypeptide-related sequence A (MICA) in prostate cancer. Experimental and molecular pathology, 108, 173-182.

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For research use only. Not intended for any clinical use.

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