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MAPKAPK5 Matched Antibody Pair (717) (APMAB-717LY)


See all MAPKAPK5 antibodies
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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-MAPKAPK5 polyclonal antibody, 100 ug
Detection Antibody
Anti-MAPKAPK5 Mouse polyclonal antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012]
Alternative Names
Mitogen-Activated Protein Kinase-Activated Protein Kinase 5; P38-Regulated/Activated Protein Kinase; MAPK-Activated Protein Kinase 5; MAPKAP Kinase 5; EC 2.7.11.1; MAPKAP-K5; MAPKAPK-5;
Entrez Gene ID
8550
UniProt ID
Q8IW41
More Infomation

Miao, J., Gao, Y., Guan, W., Yu, X., Wang, Y., Jiang, P., ... & You, W. (2023). High level of LncRNA MAPKAPK5-AS1 predicts poor prognosis and contributes to the malignant proliferation and EMT of non-small cell lung cancer via sponging miR-490-3p from HMGB2. Genes & Genomics, 45(5), 611-625.

Zhao, Y., Zhou, D., Yuan, Y., Chen, Y., Zhang, K., Tan, Y., & Fang, S. (2023). MAPKAPK5-AS1/miR-515-5p/CAB39 Axis contributes to non-small cell lung cancer cell proliferation and migration. Molecular Biotechnology, 1-11.

Maroofian, R., Efthymiou, S., Suri, M., Rahman, F., Zaki, M. S., Maqbool, S., ... & Houlden, H. (2023). Consolidating the association of biallelic MAPKAPK5 pathogenic variants with a distinct syndromic neurodevelopmental disorder. Journal of Medical Genetics, 60(8), 791-796.

Vecchio, D., Cocciadiferro, D., Macchiaiolo, M., Gonfiantini, M. V., Agolini, E., Matraxia, M., ... & Bartuli, A. (2022). Expanding the novel MAPKAPK5–related developmental disorder's genotype–phenotype correlation: Patient report and 19 months of follow‐up. Clinical Genetics, 102(2), 142-148.

Peng, Z., Ouyang, X., Wang, Y., & Fan, Q. (2022). MAPKAPK5-AS1 drives the progression of hepatocellular carcinoma via regulating miR-429/ZEB1 axis. BMC Molecular and Cell Biology, 23(1), 1-11.

Wang, L., Sun, L., Liu, R., Mo, H., Niu, Y., Chen, T., ... & Liu, Q. (2021). Long non-coding RNA MAPKAPK5-AS1/PLAGL2/HIF-1α signaling loop promotes hepatocellular carcinoma progression. Journal of Experimental & Clinical Cancer Research, 40(1), 1-18.

Horn, D., Fernández-Núñez, E., Gomez-Carmona, R., Rivera-Barahona, A., Nevado, J., Schwartzmann, S., ... & Ruiz-Perez, V. L. (2021). Biallelic truncating variants in MAPKAPK5 cause a new developmental disorder involving neurological, cardiac, and facial anomalies combined with synpolydactyly. Genetics in Medicine, 23(4), 679-688.

Chen, W., Gao, G., Yan, M., Yu, M., Shi, K., & Yang, P. (2021). Long noncoding RNA MAPKAPK5-AS1 promoted lipopolysaccharide-induced inflammatory damage in the myocardium by sponging microRNA-124-3p/E2F3. Molecular Medicine, 27(1), 1-14.

Zhou, Y., Liu, S., Luo, Y., Zhang, M., Jiang, X., & Xiong, Y. (2020). IncRNA MAPKAPK5-AS1 promotes proliferation and migration of thyroid cancer cell lines by targeting miR-519e-5p/YWHAH. European journal of histochemistry: EJH, 64(4).

Ji, H., Hui, B., Wang, J., Zhu, Y., Tang, L., Peng, P., ... & Wang, K. (2019). Long noncoding RNA MAPKAPK5‐AS1 promotes colorectal cancer proliferation by partly silencing p21 expression. Cancer Science, 110(1), 72-85.

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For research use only. Not intended for any clinical use.

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