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MAPK10 Matched Antibody Pair (714) (APMAB-714LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-MAPK10 monoclonal, IgG1 antibody, 100 ug
Detection Antibody
Anti-MAPK10 Biotinylated mouse monoclonal, IgG1 antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
Alternative Names
Mitogen-Activated Protein Kinase 10; Stress-Activated Protein Kinase JNK3; Stress-Activated Protein Kinase 1b; C-Jun N-Terminal Kinase 3; MAP Kinase P49 3F12; MAP Kinase 10; EC 2.7.11.24; PRKM10; SAPK1b;
Entrez Gene ID
5602
UniProt ID
P53779
More Infomation

Deng, Y. W., Liu, F., Li, Z. T., Gao, J. H., Zhao, Y., Yang, X. L., & Xia, Y. L. (2022). Hyperglycemia promotes myocardial dysfunction via the ERS-MAPK10 signaling pathway in db/db mice. Laboratory Investigation, 102(11), 1192-1202.

Zhang, Y., Long, Y., Liu, Y., Yang, M., Wang, L., Liu, X., ... & Luo, Y. (2022). MAPK5 and MAPK10 overexpression influences strawberry fruit ripening, antioxidant capacity and resistance to Botrytis cinerea. Planta, 255(1), 19.

Liu, F., Deng, Y., Zhao, Y., Li, Z., Gao, J., Zhang, Y., ... & Xia, Y. (2022). Time series RNA-seq analysis identifies MAPK10 as a critical gene in diabetes mellitus-induced atrial fibrillation in mice. Journal of Molecular and Cellular Cardiology, 168, 70-82.

Gao, Y., Wang, Y., Wang, X., Zhao, C., Wang, F., Du, J., ... & Zhang, J. (2021). miR-335-5p suppresses gastric cancer progression by targeting MAPK10. Cancer Cell International, 21(1), 1-12.

Li, H., Li, Y., Zhang, Y., Tan, B., Huang, T., Xiong, J., ... & Fu, L. (2021). MAPK10 Expression as a Prognostic Marker of the Immunosuppressive Tumor Microenvironment in Human Hepatocellular Carcinoma. Frontiers in Oncology, 11, 687371.

Wu, X., Li, X., & Xu, G. (2020). Propofol suppresses the progression of non‑small cell lung cancer via downregulation of the miR‑21‑5p/MAPK10 axis. Oncology Reports, 44(2), 487-498.

Sun, R., Xiang, T., Tang, J., Peng, W., Luo, J., Li, L., ... & Tao, Q. (2020). 19q13 KRAB zinc-finger protein ZNF471 activates MAPK10/JNK3 signaling but is frequently silenced by promoter CpG methylation in esophageal cancer. Theranostics, 10(5), 2243.

Zhang, L., Li, H., Yuan, M., Li, M., & Zhang, S. (2019). Cervical cancer cells-secreted exosomal microRNA-221-3p promotes invasion, migration and angiogenesis of microvascular endothelial cells in cervical cancer by down-regulating MAPK10 expression. Cancer management and research, 10307-10319.

Xie, Y., Liu, Y., Fan, X., Zhang, L., Li, Q., Li, S., ... & Xiao, Y. (2019). MicroRNA-21 promotes progression of breast cancer via inhibition of mitogen-activated protein kinase10 (MAPK10). Bioscience reports, BSR20181000-BSR20181000.

Liu, J., & Li, Y. (2019). Upregulation of MAPK10, TUBB2B and RASL11B may contribute to the development of neuroblastoma. Molecular medicine reports, 20(4), 3475-3486.

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For research use only. Not intended for any clinical use.

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