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Human Kidney Biomarker Antibody Array (Membrane, 38 Targets) (Y0252) (AbAr-0252-YC)


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Specifications

Target Array
Kidney Biomarker Array
Target
Adiponectin, Fetuin A, Renin, Aminopeptidase N, CXCL1, Resistin, Angiotensinogen/Serpin A8, IL-1ra, SCF, Annexin V, IL-6, Serpin A3, beta2-Microglobulin, IL-10, TNF-alpha, Clusterin, TIM-1, TNF RI, CXCL16, NGAL, Trefoil Factor 3, Cyr61/CCN, CCL2, Thrombospondin-1, Cystatin C, MMP-9, TWEAK, DPPIV, Neprilysin, uPA, EGF, PSA/KLK-3, VCAM-1, ErbB1, RAGE, VEGF-A, FABP1/L-FABP, RBP-4
Species Reactivity
Human

Applications

Application
Multiplex Protein Detection
Solid Support
Membrane
Detection Assay
Sandwich-based
Protocol Outline
Apply a blocking agent to the membranes.
Proceed with sample incubation.
Incubate using the cocktail of biotinylated detection antibodies.
Incubate with streptavidin conjugated to horseradish peroxidase (HRP).
Conduct incubation with the detection buffers.
Utilize a chemiluminescent imaging system for image capture.
Execute densitometric evaluation and perform data analysis.
Components
Antibody Array Membrane
Labeling Reagent
Blocking Buffer
Wash Buffer
Detection Buffer
Detection Cocktail
Others
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Once thawed, please keep reagents under suitable conditions respectively. Do not use past expiration date.

Background

Introduction
Legacy kidney biomarkers include serum creatinine (sCr), blood urea nitrogen (BUN), urinary albumin/protein and volume excretion. However, sCr or BUN cannot distinguish injury from hemodynamic changes in the kidney that lead to appropriate changes in glomerular filtration rate (GFR), particularly when the changes are acute. Furthermore, sCr or BUN cannot change quickly enough with injury since individuals with normal renal function have a functional reserve that is brought into play in response to nephron injury. Other nephrons increase their function so that sCr and BUN may not move out of the "normal range" until there is a great deal of injury and potentially irreversible loss of nephrons. Thus GFR, whether measured by sCr or by more direct methods such as iohexol clearance, is a measure of function of the kidney which is clearly important but which may not move in sync with injury under all circumstances.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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