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IL6 Matched Antibody Pair (636) (APMAB-636LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-IL6 monoclonal antibody, 100 ug
Detection Antibody
Anti-IL6 Rabbit polyclonal antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Alternative Names
Interleukin 6
Entrez Gene ID
3569
UniProt ID
P05231
More Infomation

McAndrews, K. M., Chen, Y., Darpolor, J. K., Zheng, X., Yang, S., Carstens, J. L., ... & Kalluri, R. (2022). Identification of functional heterogeneity of carcinoma-associated fibroblasts with distinct IL6-mediated therapy resistance in pancreatic cancer. Cancer discovery, 12(6), 1580-1597.

Martínez-Pérez, C., Kay, C., Meehan, J., Gray, M., Dixon, J. M., & Turnbull, A. K. (2021). The IL6-like cytokine family: Role and biomarker potential in breast cancer. Journal of personalized medicine, 11(11), 1073.

Jing, B., Wang, T., Sun, B., Xu, J., Xu, D., Liao, Y., ... & Deng, J. (2020). IL6/STAT3 signaling orchestrates premetastatic niche formation and immunosuppressive traits in lung. Cancer research, 80(4), 784-797.

Siersbæk, R., Scabia, V., Nagarajan, S., Chernukhin, I., Papachristou, E. K., Broome, R., ... & Carroll, J. S. (2020). IL6/STAT3 signaling hijacks estrogen receptor α enhancers to drive breast cancer metastasis. Cancer Cell, 38(3), 412-423.

Rossotti, R., Travi, G., Ughi, N., Corradin, M., Baiguera, C., Fumagalli, R., ... & Niguarda COVID-19 Working Group. (2020). Safety and efficacy of anti-il6-receptor tocilizumab use in severe and critical patients affected by coronavirus disease 2019: A comparative analysis. Journal of Infection, 81(4), e11-e17.

Rosa, M., Chignon, A., Li, Z., Boulanger, M. C., Arsenault, B. J., Bossé, Y., ... & Mathieu, P. (2019). A Mendelian randomization study of IL6 signaling in cardiovascular diseases, immune-related disorders and longevity. NPJ genomic medicine, 4(1), 23.

Qiao, Y., Zhang, C., Li, A., Wang, D., Luo, Z., Ping, Y., ... & Zhang, Y. (2018). IL6 derived from cancer-associated fibroblasts promotes chemoresistance via CXCR7 in esophageal squamous cell carcinoma. Oncogene, 37(7), 873-883.

Cheng, Y., Li, H., Deng, Y., Tai, Y., Zeng, K., Zhang, Y., ... & Yang, Y. (2018). Cancer-associated fibroblasts induce PDL1+ neutrophils through the IL6-STAT3 pathway that foster immune suppression in hepatocellular carcinoma. Cell death & disease, 9(4), 422.

Kato, T., Noma, K., Ohara, T., Kashima, H., Katsura, Y., Sato, H., ... & Fujiwara, T. (2018). Cancer-associated fibroblasts affect intratumoral CD8+ and FoxP3+ T cells via IL6 in the tumor microenvironment. Clinical Cancer Research, 24(19), 4820-4833.

Tsukamoto, H., Fujieda, K., Miyashita, A., Fukushima, S., Ikeda, T., Kubo, Y., ... & Oshiumi, H. (2018). Combined blockade of IL6 and PD-1/PD-L1 signaling abrogates mutual regulation of their immunosuppressive effects in the tumor microenvironment. Cancer research, 78(17), 5011-5022.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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