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HOOK1 Matched Antibody Pair (563) (APMAB-563LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-HOOK1 polyclonal antibody, 100 ug
Detection Antibody
Anti-HOOK1 Mouse monoclonal, IgG2a antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes a member of the hook family of coiled-coil proteins, which bind to microtubules and organelles through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate subcellular structures, and interacts with several members of the Rab GTPase family involved in endocytosis. It is thought to link endocytic membrane trafficking to the microtubule cytoskeleton. Several alternatively spliced transcript variants have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Alternative Names
Hook Microtubule Tethering Protein 1; H-Hook1; HHK1; Hook Homolog 1 (Drosophila); Protein Hook Homolog 1; Hook Homolog 1; HK1;
Entrez Gene ID
51361
UniProt ID
Q9UJC3
More Infomation

Yin, L., Li, W., Chen, X., Wang, R., Zhang, T., Meng, J., ... & Yang, H. (2023). HOOK1 Inhibits the Progression of Renal Cell Carcinoma via TGF‐β and TNFSF13B/VEGF‐A Axis. Advanced Science, 2206955.

Higashi, S., Makiyama, T., Sakane, H., Nogami, S., & Shirataki, H. (2022). Regulation of Hook1-mediated endosomal sorting of clathrin-independent cargo by γ-taxilin. Journal of Cell Science, 135(1), jcs258849.

Yang, H., He, L., Zhang, Y., Li, Y., Huang, X., Li, Y., ... & Wang, L. (2020). The clinicopathological and prognostic implications of tyrosine phosphatase SHP2 and ankyrin Hook1 gene expression in non-small cell lung cancer patients treated with gemcitabine plus platinum as first-line chemotherapy. Annals of Palliative Medicine, 9(5), 2943952-2942952.

Olenick, M. A., Dominguez, R., & Holzbaur, E. L. (2019). Dynein activator Hook1 is required for trafficking of BDNF-signaling endosomes in neurons. Journal of Cell Biology, 218(1), 220-233.

He, L., Li, Y., Huang, X., Cheng, H., Ke, Y., & Wang, L. (2019). The prognostic significance of SHP2 and its binding protein Hook1 in non-small cell lung cancer. OncoTargets and therapy, 12, 5897.

Xie, J. C., Ma, X. Y., Liu, X. H., Yu, J., Zhao, Y. C., Tan, Y., ... & Zhao, Y. X. (2018). Hypoxia increases amyloid-β level in exosomes by enhancing the interaction between CD147 and Hook1. American Journal of Translational Research, 10(1), 150.

Sheikh, T. I., Harripaul, R., Ayub, M., & Vincent, J. B. (2018). MeCP2 AT‐Hook1 mutations in patients with intellectual disability and/or schizophrenia disrupt DNA binding and chromatin compaction in vitro. Human Mutation, 39(5), 717-728.

Cao, J., Huang, Y. Q., Lan, X. B., & Ge, M. H. (2018). Clinicopathological and prognostic significance of SHP2 and Hook1 expression in patients with thyroid carcinoma. Human Pathology, 81, 105-112.

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For research use only. Not intended for any clinical use.

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