HMGCL Matched Antibody Pair (560) (APMAB-560LY)

Name: HMGCL Matched Antibody Pair (560)
SKU: APMAB-560LY
Rating: 5 (1 reviews)

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Datasheet

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Mouse anti-HMGCL monoclonal antibody, 100 ug

Detection Antibody

Anti-HMGCL Rabbit polyclonal antibody, 50 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

The protein encoded by this gene belongs to the HMG-CoA lyase family. It is a mitochondrial enzyme that catalyzes the final step of leucine degradation and plays a key role in ketone body formation. Mutations in this gene are associated with HMG-CoA lyase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Alternative Names

3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase; 3-Hydroxymethyl-3-Methylglutaryl-Coenzyme A Lyase; 3-Hydroxy-3-Methylglutarate-CoA Lyase; Hydroxymethylglutaricaciduria; HMG-CoA Lyase; EC 4.1.3.4;

Entrez Gene ID

3155

UniProt ID

P35914

More Infomation

References

Zhong, C., Xiong, G., Yang, H., Du, X., Du, J., Yao, F., ... & Deng, Y. (2023). Phosphorylation by IKKβ promotes the degradation of HMGCL via NEDD4 in lung cancer. International Journal of Biological Sciences, 19(4), 1110.

Cui, X., Yun, X., Sun, M., Li, R., Lyu, X., Lao, Y., ... & Yu, W. (2023). HMGCL-induced β-hydroxybutyrate production attenuates hepatocellular carcinoma via DPP4-mediated ferroptosis susceptibility. Hepatology International, 17(2), 377-392.

Li, Y., Fan, Z., Yin, D., Jiang, R., Deng, J., & Song, X. (2022). HMGCL: Heterogeneous multigraph contrastive learning for LBSN friend recommendation. World Wide Web, 1-24.

Kil, E. J. B. (2018). CRISPR-Cas9 mediated HMGCL KO in 3xTg AD mice reduces the cognitive deficit improvement seen in an intermittent metabolic switching regimen.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-HMGCL Recombinant Antibody (4F4-D1)

Mouse Anti-HMGCL Recombinant Antibody (CBFYH-1545)

Mouse Anti-HMGCL Recombinant Antibody (9F5AB9)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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