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HERPUD1 Matched Antibody Pair (537) (APMAB-537LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-HERPUD1 polyclonal antibody, 100 ug
Detection Antibody
Anti-HERPUD1 Mouse monoclonal, IgG1 antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. The full-length nature of all transcript variants has not been determined. [provided by RefSeq, Jan 2013]
Alternative Names
Homocysteine Inducible ER Protein With Ubiquitin Like Domain 1; Homocysteine-Inducible, Endoplasmic Reticulum Stress-Inducible, Ubiquitin-Like Domain Member 1; Methyl Methanesulfonate (MMF)-Inducible Fragment Protein 1; Mif1; HERP; Homocysteine-Inducible Endoplasmic Reticulum Stress-Inducible Ubiquitin-Like Domain Member 1 Protein;
Entrez Gene ID
9709
UniProt ID
Q15011
More Infomation

Xie, W., Shan, Y., Wu, Z., Liu, N., Yang, J., Zhang, H., ... & Guo, H. (2023). Herpud1 deficiency alleviates homocysteine-induced aortic valve calcification. Cell Biology and Toxicology, 1-20.

Alagappan, L. P., Ramaswamy, Y., Sundaramoorthy, D. K., Bhaskar, J., Sarangapani, S., Sen, P., ... & Mathavan, S. (2023). Association of HERPUD1 genetic variant rs2217332 with age-related macular degeneration and polypoidal choroidal vasculopathy in an Indian cohort. Graefe's Archive for Clinical and Experimental Ophthalmology, 261(4), 1205-1212.

Peng, Y., Li, N., Tang, F., Qian, C., Jia, T., Liu, J., & Xu, Y. (2022). Corosolic acid sensitizes ferroptosis by upregulating HERPUD1 in liver cancer cells. Cell Death Discovery, 8(1), 376.

Nie, X., Liu, D., Zheng, M., Li, X., Liu, O., Guo, Q., ... & Lin, B. (2022). HERPUD1 promotes ovarian cancer cell survival by sustaining autophagy and inhibit apoptosis via PI3K/AKT/mTOR and p38 MAPK signaling pathways. BMC cancer, 22(1), 1338.

Mikawa, M., Sakai, C., Yamamoto, T., Nakamura, Y., Tanaka, S., Tominaga, N., ... & Yano, M. (2022). Herpud1 suppress angiotensin II induced hypertrophy in cardiomyocytes. Biochemistry and Biophysics Reports, 30, 101248.

Li, W., Wang, Y., Zhu, L., Du, S., Mao, J., Wang, Y., ... & Yi, Q. (2021). The P300/XBP1s/Herpud1 axis promotes macrophage M2 polarization and the development of choroidal neovascularization. Journal of Cellular and Molecular Medicine, 25(14), 6709-6720.

Liu, C., Xu, X., Huang, C., Zhang, L., Shang, D., Cai, W., & Wang, Y. (2020). Circ_002664/miR-182–5p/Herpud1 pathway importantly contributes to OGD/R-induced neuronal cell apoptosis. Molecular and cellular probes, 53, 101585.

Li, Y., Xie, Y., Hao, J., Liu, J., Ning, Y., Tang, Q., ... & Lv, X. (2018). ER-localized protein-Herpud1 is a new mediator of IL-4-induced macrophage polarization and migration. Experimental Cell Research, 368(2), 167-173.

Navarro-Marquez, M., Torrealba, N., Troncoso, R., Vásquez-Trincado, C., Rodriguez, M., Morales, P. E., ... & Lavandero, S. (2018). Herpud1 impacts insulin-dependent glucose uptake in skeletal muscle cells by controlling the Ca2+-calcineurin-Akt axis. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1864(5), 1653-1662.

Américo-Da-Silva, L., Diaz, J., Bustamante, M., Mancilla, G., Oyarzun, I., Verdejo, H. E., & Quiroga, C. (2018). A new role for HERPUD1 and ERAD activation in osteoblast differentiation and mineralization. The FASEB Journal, 32(9), 4681-4695.

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For research use only. Not intended for any clinical use.

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