HCK Matched Antibody Pair (528) (APMAB-528LY)

Name: HCK Matched Antibody Pair (528)
SKU: APMAB-528LY
Rating: 5 (1 reviews)

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Datasheet

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Rabbit anti-HCK polyclonal antibody, 100 ug

Detection Antibody

Anti-HCK Mouse monoclonal, IgG1 antibody, 20 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010]

Alternative Names

HCK Proto-Oncogene, Src Family Tyrosine Kinase; Hemopoietic Cell Kinase; Hematopoietic Cell Kinase; P59-HCK/P60-HCK; EC 2.7.10.2; P59Hck;

Entrez Gene ID

3055

UniProt ID

P08631

More Infomation

References

Premanand, A., & Reena Rajkumari, B. (2023). Bioinformatic analysis of gene expression data reveals Src family protein tyrosine kinases as key players in androgenetic alopecia. Frontiers in Medicine, 10, 1108358.

Portugal, C. C., Almeida, T. O., Socodato, R., & Relvas, J. B. (2022). Src family kinases (SFKs): critical regulators of microglial homeostatic functions and neurodegeneration in Parkinson's and Alzheimer's diseases. The FEBS Journal, 289(24), 7760-7775.

Pond, M. P., Eells, R., Treece, B. W., Heinrich, F., Lösche, M., & Roux, B. (2020). Membrane anchoring of Hck kinase via the intrinsically disordered SH4-U and length scale associated with subcellular localization. Journal of molecular biology, 432(9), 2985-2997.

Sirvent, A., Mevizou, R., Naim, D., Lafitte, M., & Roche, S. (2020). Src family tyrosine kinases in intestinal homeostasis, regeneration and tumorigenesis. Cancers, 12(8), 2014.

Patel, R. K., Weir, M. C., Shen, K., Snyder, D., Cooper, V. S., & Smithgall, T. E. (2019). Expression of myeloid Src-family kinases is associated with poor prognosis in AML and influences Flt3-ITD kinase inhibitor acquired resistance. PLoS One, 14(12), e0225887.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

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Mouse Anti-HCK Recombinant Antibody (CBFYH-0774)

Mouse Anti-HCK Recombinant Antibody (2A6)

Mouse Anti-HCK Monoclonal Antibody (CBFYH-3027)

Mouse Anti-HCK Recombinant Antibody (CBFYH-0771)

Rabbit Anti-HCK Recombinant Antibody (E1I7F)

Mouse Anti-HCK Recombinant Antibody (CBFYH-0776)

Mouse Anti-HCK Recombinant Antibody (3D12E10)

Mouse Anti-HCK ( AA 1-50) Monoclonal Antibody (CBFYH-3028)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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