GSTA3 Matched Antibody Pair (507) (APMAB-507LY)

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Datasheet

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Rabbit anti-GSTA3 polyclonal antibody, 100 ug

Detection Antibody

Anti-GSTA3 Mouse monoclonal, IgG2a antibody, 20 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity. The enzyme encoded by this gene catalyzes the double bond isomerization of precursors for progesterone and testosterone during the biosynthesis of steroid hormones. An additional transcript variant has been identified, but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]

Alternative Names

Glutathione S-Transferase Alpha 3; Glutathione S-Transferase A3-3; Glutathione S-Transferase A3; GST Class-Alpha Member 3; EC 2.5.1.18; S-(Hydroxyalkyl)Glutathione Lyase A3;

Entrez Gene ID

2940

UniProt ID

Q16772

More Infomation

References

Xiao, Y., Zhang, Z., Fu, Y., Shan, H., Cui, S., & Wu, J. (2019). GSTA3 regulates TGF-β 1-induced renal interstitial fibrosis in NRK-52E cells as a component of the PI3K–Keap1/Nrf2 pathway. Journal of International Medical Research, 47(11), 5787-5801.

Yi, L., Mu, H., Hu, N., Sun, J., Yin, J., Dai, K., ... & Ding, D. (2018). Differential expression of NPM, GSTA3, and GNMT in mouse liver following long-term in vivo irradiation by means of uranium tailings. Bioscience reports, 38(5).

Duan, S., Gong, B., Wang, P., Huang, H., Luo, L., & Liu, F. (2018). Novel prognostic biomarkers of gastric cancer based on gene expression microarray: COL12A1, GSTA3, FGA and FGG. Molecular medicine reports, 18(4), 3727-3736.

Jia, F., Niu, S., Zhang, N., Li, X., Ning, G., Zhang, D., ... & Tian, W. (2018). The effection of recombinant protein GSTA3 on the transcription of erythrocytes immune related genes in Tibial Dyschondroplasia broilers induced by Thiram. Acta Veterinaria et Zootechnica Sinica, 49(4), 811-817.

Ma, V. W. S., Cheung, G. H. Y., Lau, E. Y. T., & Cho, W. C. S. (2018). Xenobiotic detoxification enzymes and cancer risk: A multiplex immunofluorescence detection of AE1/AE3, GSTA1 and GSTA3 in the tissue microarrays of gastrointestinal tract. Cancer Research, 78(13_Supplement), 3597-3597.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Second antibody and isotype control

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