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GRN Matched Antibody Pair (502) (APMAB-502LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-GRN monoclonal antibody, 100 ug
Detection Antibody
Anti-GRN Biotinylated mouse monoclonal, IgG2a antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008]
Alternative Names
Granulin Precursor; Proepithelin; Progranulin; PEPI; PC Cell-Derived Growth Factor; Granulin-Epithelin; Acrogranin;
Entrez Gene ID
2896
UniProt ID
P28799
More Infomation

Boland, S., Swarup, S., Ambaw, Y. A., Malia, P. C., Richards, R. C., Fischer, A. W., ... & Farese Jr, R. V. (2022). Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis. Nature Communications, 13(1), 5924.

Zhou, X., Kukar, T., & Rademakers, R. (2021). Lysosomal dysfunction and other pathomechanisms in FTLD: evidence from progranulin genetics and biology. Frontotemporal Dementias: Emerging Milestones of the 21st Century, 219-242.

Petkau, T. L., Life, B., Lu, G., Yang, J., Fornes, O., Wasserman, W., ... & Leavitt, B. R. (2021). Human progranulin-expressing mice as a novel tool for the development of progranulin-modulating therapeutics. Neurobiology of Disease, 153, 105314.

Boland, S., Swarup, S., Ambaw, Y. A., Richards, R. C., Fischer, A. W., Singh, S., ... & Farese Jr, R. V. (2021). Progranulin deficiency results in reduced bis (monoacylglycero) phosphate (BMP) levels and gangliosidosis. bioRxiv, 2021-09.

Klupp, F., Kahlert, C., Franz, C., Halama, N., Schleussner, N., Wirsik, N. M., ... & Ulrich, A. B. (2021). Granulin: an invasive and survival-determining marker in colorectal cancer patients. International Journal of Molecular Sciences, 22(12), 6436.

Bhopatkar, A. A., Uversky, V. N., & Rangachari, V. (2020). Granulins modulate liquid–liquid phase separation and aggregation of the prion-like C-terminal domain of the neurodegeneration-associated protein TDP-43. Journal of Biological Chemistry, 295(8), 2506-2519.

Bateman, A., Cheung, S. T., & Bennett, H. P. (2018). A brief overview of progranulin in health and disease. Progranulin: Methods and Protocols, 3-15.

Paushter, D. H., Du, H., Feng, T., & Hu, F. (2018). The lysosomal function of progranulin, a guardian against neurodegeneration. Acta neuropathologica, 136, 1-17.

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For research use only. Not intended for any clinical use.

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